PMID- 10348342
OWN - NLM
STAT- MEDLINE
DCOM- 19990616
LR  - 20220408
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 17
DP  - 1999 Apr 29
TI  - Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor
      tyrosine kinase.
PG  - 2681-9
AB  - The ErbB/HER family of receptor tyrosine kinases consists of four receptors that 
      bind a large number of growth factor ligands sharing an epidermal growth factor- 
      (EGF)-like motif. Whereas ErbB-1 binds seven different ligands whose prototype is
      EGF, the three families of neuregulins (NRGs) activate ErbB-3 and/or ErbB-4. Here
      we characterize a fourth neuregulin, NRG-4, that acts through ErbB-4. The
      predicted pro-NRG-4 is a transmembrane protein carrying a unique EGF-like motif
      and a short cytoplasmic domain. A synthetic peptide encompassing the full-length 
      EGF-like domain can induce growth of interleukin-dependent cells ectopically
      expressing ErbB-4, but not cells expressing the other three ErbB proteins or
      their combinations. Consistent with specificity to ErbB-4, NRG-4 can displace an 
      ErbB-4-bound NRG-1 and can activate signaling downstream of this receptor.
      Expression of NRG-4 mRNA was detected in the adult pancreas and weakly in muscle;
      other tissues displayed no detectable NRG-4 mRNA. The primary structure and the
      pattern of expression of NRG-4, together with the strict specificity of this
      growth factor to ErbB-4, suggest a physiological role distinct from that of the
      known ErbB ligands.
FAU - Harari, D
AU  - Harari D
AD  - Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, 
      Israel.
FAU - Tzahar, E
AU  - Tzahar E
FAU - Romano, J
AU  - Romano J
FAU - Shelly, M
AU  - Shelly M
FAU - Pierce, J H
AU  - Pierce JH
FAU - Andrews, G C
AU  - Andrews GC
FAU - Yarden, Y
AU  - Yarden Y
LA  - eng
SI  - GENBANK/AF083067
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Glycoproteins)
RN  - 0 (Ligands)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuregulins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (ERBB4 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-4)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Division/physiology
MH  - ErbB Receptors/*physiology
MH  - Glycoproteins/*physiology
MH  - Humans
MH  - Ligands
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*physiology
MH  - Neuregulins
MH  - Organ Specificity
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/biosynthesis
MH  - Receptor, ErbB-4
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - 10.1038/sj.onc.1202631 [doi]
PST - ppublish
SO  - Oncogene. 1999 Apr 29;18(17):2681-9. doi: 10.1038/sj.onc.1202631.