PMID- 10347196
OWN - NLM
STAT- MEDLINE
DCOM- 19990701
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 23
DP  - 1999 Jun 4
TI  - Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts
      with CREB-binding protein.
PG  - 16370-6
AB  - The ability of cAMP response-element binding protein (CREB)-binding protein (CBP)
      to function as a co-activator for a number of transcription factors appears to be
      mediated by its ability to act as a histone acetyltransferase and through its
      interaction with a number of other proteins (general transcription factors,
      histone acetyltransferases, and other co-activators). Here we report that CBP
      also interacts with a novel ATPase termed Snf2-Related CBP Activator Protein
      (SRCAP). Consistent with this activity, SRCAP contains the conserved ATPase
      domain found within members of the Snf2 family. Transfection experiments
      demonstrate that SRCAP is able to activate transcription when expressed as a
      Gal-SRCAP chimera and that SRCAP also enhances the ability of CBP to activate
      transcription. The adenoviral protein E1A was found to disrupt interaction
      between SRCAP and CBP possibly representing a mechanism for E1A-mediated
      transcriptional repression.
FAU - Johnston, H
AU  - Johnston H
AD  - Department of Pharmacological and Physiological Sciences, Saint Louis University,
      Saint Louis, Missouri 63104, USA.
FAU - Kneer, J
AU  - Kneer J
FAU - Chackalaparampil, I
AU  - Chackalaparampil I
FAU - Yaciuk, P
AU  - Yaciuk P
FAU - Chrivia, J
AU  - Chrivia J
LA  - eng
SI  - GENBANK/AF143946
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Adenovirus E1A Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (CREBBP protein, human)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.4.- (SRCAP protein, human)
SB  - IM
MH  - Adenosine Triphosphatases/chemistry/genetics/*metabolism
MH  - Adenovirus E1A Proteins/pharmacology
MH  - Amino Acid Sequence
MH  - CREB-Binding Protein
MH  - Gene Library
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*metabolism
MH  - Trans-Activators/*metabolism
MH  - Transcriptional Activation
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - 10.1074/jbc.274.23.16370 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Jun 4;274(23):16370-6. doi: 10.1074/jbc.274.23.16370.