PMID- 10346978
OWN - NLM
STAT- MEDLINE
DCOM- 19990728
LR  - 20061115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 11
IP  - 6
DP  - 1999 Jun
TI  - Identification and characterization of SIGIRR, a molecule representing a novel
      subtype of the IL-1R superfamily.
PG  - 389-99
AB  - A novel member of the interleukin 1 receptor (IL-1R) superfamily, SIGIRR (single 
      Ig IL-1R-related molecule) was identified in mouse and human. Although it shows
      the typical conserved motifs that characterize the IL-1R and Toll superfamily, it
      is structurally and functionally distinct from both. SIGIRR has only one Ig
      domain in its extracellular portion whereas the IL-1R family contains three Ig
      folds. An unusually long cytoplasmic domain is reminiscent of the structure of
      drosophila Toll, yet the SIGIRR peptide sequence is more closely related to
      IL-1RI. The human SIGIRR gene maps to 11p15. 5 and thus is not located in the
      same cluster on chromosome 2 that is known to contain four members of the IL-1R
      family. It failed to bind to the known IL-1-family members and, when co-expressed
      with the IL-1RI, had no effect on the binding of IL-1 and on subsequent nuclear
      factor kappaB (NFkappaB) activation. A chimera, in which the SIGIRR intracellular
      domain was fused to the IL-1R extracellular domain, did not activate NFkappaB
      unlike similar fusion proteins of other IL-1R related molecules. We conclude that
      the SIGIRR protein represents a novel subtype of the IL-1R superfamily.
CI  - Copyright 1999 Academic Press.
FAU - Thomassen, E
AU  - Thomassen E
AD  - Immunex Corporation, Seattle, WA 98101, USA.
FAU - Renshaw, B R
AU  - Renshaw BR
FAU - Sims, J E
AU  - Sims JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Immunoglobulins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Interleukin-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigen-Antibody Reactions
MH  - Blotting, Western
MH  - Cell Line
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Humans
MH  - Immunoglobulins/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, Interleukin-1/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction/physiology
EDAT- 1999/05/29 00:00
MHDA- 1999/05/29 00:01
CRDT- 1999/05/29 00:00
PHST- 1999/05/29 00:00 [pubmed]
PHST- 1999/05/29 00:01 [medline]
PHST- 1999/05/29 00:00 [entrez]
AID - S1043-4666(98)90452-5 [pii]
AID - 10.1006/cyto.1998.0452 [doi]
PST - ppublish
SO  - Cytokine. 1999 Jun;11(6):389-99. doi: 10.1006/cyto.1998.0452.