PMID- 10344735
OWN - NLM
STAT- MEDLINE
DCOM- 19990617
LR  - 20070424
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 10
DP  - 1999 May 15
TI  - Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the
      TCL1 locus.
PG  - 2313-7
AB  - The region on chromosome 14q32.1 is frequently involved in chromosomal
      translocations and inversions with one of the T-cell receptor loci in human
      T-cell leukemias and lymphomas. The breakpoints of the different rearrangements
      segregate into two clusters: inversion on the centromeric side and simple
      balanced translocations on the telomeric side. If the target gene activated by
      these different types of chromosomal rearrangements is the same, the gene must
      reside between the two clusters of breakpoints in a region of approximately 160
      kb. By screening of a placenta cDNA library using genomic probes derived from the
      vicinity of TCL1 locus, we have identified a gene coding for a 1.7-kb transcript 
      that is expressed in leukemic cells carrying a t(14;14)(q11;q32) chromosome
      translocation. The cognate cDNA sequence reveals an open reading frame of 384
      nucleotides encoding a Mr 15,000 protein with approximately 30% of homology with 
      both p14TCL1 and p13MTCP1 oncoproteins. The genomic organization of the TML1
      locus was characterized, with three exons located 15 kb from and tail-to-tail in 
      relation to TCL1 locus. Because of its location and sequence similarity with TCL1
      and MTCP1 oncoproteins, this gene, named TML1 (TCL1/MTCP1-like 1) is a candidate 
      gene that is potentially involved in leukemogenesis.
FAU - Sugimoto, J
AU  - Sugimoto J
AD  - Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama
      University, Toyama City, Japan.
FAU - Hatakeyama, T
AU  - Hatakeyama T
FAU - Narducci, M G
AU  - Narducci MG
FAU - Russo, G
AU  - Russo G
FAU - Isobe, M
AU  - Isobe M
LA  - eng
SI  - GENBANK/AB018563
SI  - GENBANK/AB025272
SI  - GENBANK/AB025273
SI  - GENBANK/AB025274
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MTCP1 protein, human)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TCL1A protein, human)
RN  - 0 (TCL1B protein, human)
RN  - 0 (Tcl1 protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - DNA, Neoplasm/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression
MH  - Humans
MH  - Leukemia/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Oncogene Proteins/*genetics
MH  - *Oncogenes
MH  - Proto-Oncogene Proteins/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 1999/05/27 00:00
MHDA- 1999/05/27 00:01
CRDT- 1999/05/27 00:00
PHST- 1999/05/27 00:00 [pubmed]
PHST- 1999/05/27 00:01 [medline]
PHST- 1999/05/27 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 May 15;59(10):2313-7.