PMID- 10343098
OWN - NLM
STAT- MEDLINE
DCOM- 19990625
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 84
IP  - 1-2
DP  - 1999
TI  - Physical mapping of the CXC chemokine locus on human chromosome 4.
PG  - 39-42
AB  - A physical map of the CXC chemokine locus on chromosome 4 has been constructed by
      PCR analysis and PFGE mapping of YAC clones. The genes for IL8, GRO1, PPBP, PF4, 
      SCYB5 (ENA-78) and SCYB6 (GCP-2) have been co-localized on a 335-kb genomic
      fragment. The GRO2 and GRO3 genes did not map within this region and based on
      analysis of a YAC contig overlapping IL8 we speculate that GRO2 and GRO3 map
      downstream of this region. We have also assigned the novel CXC chemokine gene,
      SCYB9B (alias H174/betaR1) to chromosome 4q21, upstream and within 12 kb of
      INP10. Like INP10 and MIG, INP10 and SCYB9B are arranged in a head to tail
      manner. The chromosomal arrangement of these genes appears to reflect the
      evolution of this multigene family and supports the theory that it arose by gene 
      duplication.
FAU - O'Donovan, N
AU  - O'Donovan N
AD  - Department of Microbiology, University College Cork, Cork, Ireland.
FAU - Galvin, M
AU  - Galvin M
FAU - Morgan, J G
AU  - Morgan JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (CXCL1 protein, human)
RN  - 0 (CXCL3 protein, human)
RN  - 0 (CXCL5 protein, human)
RN  - 0 (CXCL6 protein, human)
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Chemokine CXCL5)
RN  - 0 (Chemokine CXCL6)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-8)
RN  - 37270-94-3 (Platelet Factor 4)
SB  - IM
MH  - Biological Evolution
MH  - Chemokine CXCL1
MH  - Chemokine CXCL5
MH  - Chemokine CXCL6
MH  - Chemokines, CXC/*genetics
MH  - Chemotactic Factors/genetics
MH  - Chromosomes, Artificial, Yeast/genetics
MH  - Chromosomes, Human, Pair 4/*genetics
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Gene Duplication
MH  - Growth Substances/genetics
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Interleukin-8/analogs & derivatives/genetics
MH  - Multigene Family
MH  - Phylogeny
MH  - Physical Chromosome Mapping
MH  - Platelet Factor 4/genetics
MH  - Polymerase Chain Reaction
MH  - Restriction Mapping
EDAT- 1999/05/27 06:00
MHDA- 2000/08/16 11:00
CRDT- 1999/05/27 06:00
PHST- 1999/05/27 06:00 [pubmed]
PHST- 2000/08/16 11:00 [medline]
PHST- 1999/05/27 06:00 [entrez]
AID - 15209 [pii]
AID - 10.1159/000015209 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;84(1-2):39-42. doi: 10.1159/000015209.