PMID- 10339464
OWN - NLM
STAT- MEDLINE
DCOM- 19990624
LR  - 20171116
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 93
IP  - 11
DP  - 1999 Jun 1
TI  - The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently
      rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid
      tissue lymphomas.
PG  - 3601-9
AB  - Marginal zone cell lymphomas of the mucosa-associated lymphoid tissue (MALT) are 
      the most common subtype of lymphoma arising at extranodal sites. The
      t(11;18)(q21;q21) appears to be the key genetic lesion and is found in
      approximately 50% of cytogenetically abnormal low-grade MALT lymphomas. We show
      that the API2 gene, encoding an inhibitor of apoptosis also known as c-IAP2,
      HIAP1, and MIHC, and a novel gene on 18q21 characterized by several Ig-like
      C2-type domains, named MLT, are recurrently rearranged in the t(11;18). In both
      MALT lymphomas analyzed, the breakpoint in API2 occurred in the intron separating
      the exons coding respectively for the baculovirus IAP repeat domains and the
      caspase recruitment domain. The breakpoints within MLT differed but the open
      reading frame was conserved in both cases. In one case, the translocation was
      accompanied by a cryptic deletion involving the 3' part of API2. As a result, the
      reciprocal transcript was not present, strongly suggesting that the API2-MLT
      fusion is involved in the oncogenesis of MALT lymphoma.
FAU - Dierlamm, J
AU  - Dierlamm J
AD  - Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg,
      Germany.
FAU - Baens, M
AU  - Baens M
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Stefanova-Ouzounova, M
AU  - Stefanova-Ouzounova M
FAU - Hernandez, J M
AU  - Hernandez JM
FAU - Hossfeld, D K
AU  - Hossfeld DK
FAU - De Wolf-Peeters, C
AU  - De Wolf-Peeters C
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Van den Berghe, H
AU  - Van den Berghe H
FAU - Marynen, P
AU  - Marynen P
LA  - eng
SI  - GENBANK/AF123094
SI  - GENBANK/AF130356
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA, Complementary)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - AIM
SB  - IM
CIN - Blood. 1999 Nov 1;94(9):3270-1. PMID: 10610122
CIN - Blood. 2000 Jun 15;95(12):4014-5. PMID: 10939796
MH  - Amino Acid Sequence
MH  - Apoptosis/genetics
MH  - Base Sequence
MH  - Caspases
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 18
MH  - DNA, Complementary/analysis/genetics
MH  - Gene Rearrangement, B-Lymphocyte
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/pathology
MH  - Molecular Sequence Data
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - *Neoplasm Proteins
MH  - Proteins/*genetics
MH  - *Translocation, Genetic
EDAT- 1999/05/26 06:00
MHDA- 2000/02/19 09:00
CRDT- 1999/05/26 06:00
PHST- 1999/05/26 06:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/05/26 06:00 [entrez]
PST - ppublish
SO  - Blood. 1999 Jun 1;93(11):3601-9.