PMID- 10338208
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 97
IP  - 4
DP  - 1999 May 14
TI  - A coat protein on phagosomes involved in the intracellular survival of
      mycobacteria.
PG  - 435-47
AB  - Mycobacteria are intracellular pathogens that can survive within macrophage
      phagosomes, thereby evading host defense strategies by largely unknown
      mechanisms. We have identified a WD repeat host protein that was recruited to and
      actively retained on phagosomes by living, but not dead, mycobacteria. This
      protein, termed TACO, represents a component of the phagosome coat that is
      normally released prior to phagosome fusion with or maturation into lysosomes. In
      macrophages lacking TACO, mycobacteria were readily transported to lysosomes
      followed by their degradation. Expression of TACO in nonmacrophages prevented
      lysosomal delivery of mycobacteria and prolonged their intracellular survival.
      Active retention of TACO on phagosomes by living mycobacteria thus represents a
      mechanism preventing cargo delivery to lysosomes, allowing mycobacteria to
      survive within macrophages.
FAU - Ferrari, G
AU  - Ferrari G
AD  - Basel Institute for Immunology, Switzerland.
FAU - Langen, H
AU  - Langen H
FAU - Naito, M
AU  - Naito M
FAU - Pieters, J
AU  - Pieters J
LA  - eng
SI  - GENBANK/AF047388
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (DNA, Complementary)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Proteins)
RN  - 145420-64-0 (coronin proteins)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Intracellular Fluid
MH  - Kupffer Cells/microbiology
MH  - Macrophages/microbiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microfilament Proteins
MH  - Molecular Sequence Data
MH  - Mycobacterium bovis/*growth & development
MH  - Phagosomes/*metabolism/microbiology
MH  - Proteins/genetics/*metabolism
MH  - Rabbits
MH  - Sequence Analysis
MH  - Subcellular Fractions
MH  - Tissue Distribution
MH  - Tuberculosis/metabolism/pathology
MH  - Tumor Cells, Cultured
EDAT- 1999/05/25 00:00
MHDA- 1999/05/25 00:01
CRDT- 1999/05/25 00:00
PHST- 1999/05/25 00:00 [pubmed]
PHST- 1999/05/25 00:01 [medline]
PHST- 1999/05/25 00:00 [entrez]
AID - S0092-8674(00)80754-0 [pii]
AID - 10.1016/s0092-8674(00)80754-0 [doi]
PST - ppublish
SO  - Cell. 1999 May 14;97(4):435-47. doi: 10.1016/s0092-8674(00)80754-0.