PMID- 10337992
OWN - NLM
STAT- MEDLINE
DCOM- 19990621
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 25
IP  - 2
DP  - 1999 Jun
TI  - Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a 
      papillary thyroid carcinoma.
PG  - 97-103
AB  - In papillary thyroid carcinomas, the genes for receptor-type tyrosine kinase, RET
      or TRKA, are sometimes rearranged, resulting in fusion of its tyrosine kinase
      domain to 5' portions of several activating genes. In a papillary thyroid
      carcinoma, we identified a novel gene (ELKS), the 5' portion of which is fused to
      the RET gene by gene rearrangement due to the translocation t(10;12)(q11;p13).
      Subsequent cloning of the ELKS cDNA revealed that ELKS encodes a novel 948 amino 
      acid peptide and is expressed ubiquitously in human tissues. The presence of
      multiple coiled-coil domains in the ELKS product suggests that the ELKS protein
      forms dimers. Since the tyrosine kinase of RET is activated by dimerization that 
      occurs when its ligands bind to the receptor, fusion of RET with the 5'
      dimerization domains of ELKS would activate its cytoplasmic tyrosine kinase
      constitutively in papillary thyroid carcinomas.
FAU - Nakata, T
AU  - Nakata T
AD  - Department of Molecular Biology, Institute of Gerontology, Nippon Medical School,
      Kawasaki, Kanagawa, Japan.
FAU - Kitamura, Y
AU  - Kitamura Y
FAU - Shimizu, K
AU  - Shimizu K
FAU - Tanaka, S
AU  - Tanaka S
FAU - Fujimori, M
AU  - Fujimori M
FAU - Yokoyama, S
AU  - Yokoyama S
FAU - Ito, K
AU  - Ito K
FAU - Emi, M
AU  - Emi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Recombinant Fusion Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Ret protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Carcinoma, Papillary/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Cloning, Molecular
MH  - DNA, Neoplasm/analysis
MH  - Dimerization
MH  - *Drosophila Proteins
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protein Structure, Secondary
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins c-ret
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Recombinant Fusion Proteins/biosynthesis/genetics/physiology
MH  - Sequence Analysis, DNA
MH  - Thyroid Neoplasms/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 1999/05/25 06:00
MHDA- 2000/06/20 09:00
CRDT- 1999/05/25 06:00
PHST- 1999/05/25 06:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/05/25 06:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L [pii]
AID - 10.1002/(sici)1098-2264(199906)25:2<97::aid-gcc4>3.0.co;2-l [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Jun;25(2):97-103. doi:
      10.1002/(sici)1098-2264(199906)25:2<97::aid-gcc4>3.0.co;2-l.