PMID- 10337626
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 5
DP  - 1999 May
TI  - The 5' region of the COX4 gene contains a novel overlapping gene, NOC4.
PG  - 506-12
AB  - We identified a novel human gene, NOC4 (Neighbor Of COX4), located 5' to COX4,
      the gene for cytochrome c oxidase subunit IV, on Chr 16q32-ter. Transcripts from 
      this gene were identified among human expressed sequence tags. A full-length,
      1.06-kb human retinal NOC4 cDNA encoded a 24-kDa, 210-amino acid hypothetical
      protein of unknown function. Northern hybridization analysis of human RNAs from
      various tissues detected NOC4 transcripts of 2.2 and 1.4 kb in all tissues
      examined, suggesting that NOC4 expression is ubiquitous. Transcription of both
      the COX4 and NOC4 genes initiates within a 250-bp intergenic promoter and occurs 
      in opposite directions. The bidirectional promoter is G + C-rich, lacks TATA and 
      CCAAT elements, and contains multiple potential binding sites for Sp1 and
      NRF-2/GABP. Two of the NRF-2/GABP sites are located within 14-bp direct repeats, 
      a conserved feature of mammalian COX4 promoters. The NOC4 and COX4 genes are also
      linked in the rat, mouse, and bovine genomes. A NOC4-GFP fusion protein is
      located in both the nucleus and the cytoplasm, including the mitochondria.
FAU - Bachman, N J
AU  - Bachman NJ
AD  - Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor
      48109-0616, USA.
FAU - Wu, W
AU  - Wu W
FAU - Schmidt, T R
AU  - Schmidt TR
FAU - Grossman, L I
AU  - Grossman LI
FAU - Lomax, M I
AU  - Lomax MI
LA  - eng
SI  - GENBANK/AF005888
SI  - GENBANK/AF005889
SI  - GENBANK/AF052621
GR  - GM48800/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA, Complementary)
RN  - 0 (Recombinant Fusion Proteins)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - DNA, Complementary
MH  - Electron Transport Complex IV/*genetics
MH  - Genes, Overlapping
MH  - Humans
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Recombinant Fusion Proteins/genetics
MH  - Subcellular Fractions/metabolism
EDAT- 1999/05/25 00:00
MHDA- 1999/05/25 00:01
CRDT- 1999/05/25 00:00
PHST- 1999/05/25 00:00 [pubmed]
PHST- 1999/05/25 00:01 [medline]
PHST- 1999/05/25 00:00 [entrez]
AID - 10.1007/s003359901031 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 May;10(5):506-12. doi: 10.1007/s003359901031.