PMID- 10335655
OWN - NLM
STAT- MEDLINE
DCOM- 19990617
LR  - 20180109
IS  - 0737-4038 (Print)
IS  - 0737-4038 (Linking)
VI  - 16
IP  - 5
DP  - 1999 May
TI  - Molecular evolution of the COX7A gene family in primates.
PG  - 619-26
AB  - COX VIIa is one of 10 nuclear-encoded subunits of the COX holoenzyme, and one of 
      three that have isoforms with tissue-specific differences in expression. Analysis
      of nucleotide substitution rates revealed an accelerated rate of nonsynonymous
      substitutions relative to that of synonymous substitutions for the heart isoform 
      gene (COX7AH) in six primate lineages. Rate accelerations have been noted for
      four other COX-related genes in this time period, suggesting that the COX
      holoenzyme has experienced an episode of adaptive evolution. A third member of
      the gene family, COX7AR, has recently been described. Although its function is
      currently unknown, low nonsynonymous substitution/synonymous substitution (N/S)
      ratios in mammalian evolution suggest that COX7AR is of functional importance.
      When the COX7A isoforms were divided into domains, examination of nucleotide
      substitution rates suggested that mitochondrial targeting residues experienced an
      accelerated nonsynonymous substitution rate in the period following gene
      duplication. In contrast, paralogous comparisons of the targeting residues of
      each isoform show they have been relatively conserved in mammalian evolution.
      This pattern is consistent with the evolution of tissue-specific function.
FAU - Schmidt, T R
AU  - Schmidt TR
AD  - Center for Molecular Medicine and Genetics, Wayne State University School of
      Medicine, Detroit, Michigan 48201, USA.
FAU - Goodman, M
AU  - Goodman M
FAU - Grossman, L I
AU  - Grossman LI
LA  - eng
SI  - GENBANK/AF127780
SI  - GENBANK/AF127781
SI  - GENBANK/AF127782
SI  - GENBANK/AF127783
SI  - GENBANK/AF127784
SI  - GENBANK/AF127785
SI  - GENBANK/AF127786
SI  - GENBANK/AF127787
SI  - GENBANK/AF127788
SI  - GENBANK/AF127789
SI  - GENBANK/AF127790
SI  - GENBANK/AF127791
GR  - GM48517/GM/NIGMS NIH HHS/United States
GR  - GM48800/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Biol Evol
JT  - Molecular biology and evolution
JID - 8501455
RN  - 0 (Isoenzymes)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Electron Transport Complex IV/*genetics
MH  - *Evolution, Molecular
MH  - Genetic Variation
MH  - Humans
MH  - Isoenzymes/genetics
MH  - Molecular Sequence Data
MH  - Multigene Family/*genetics
MH  - Myocardium/enzymology
MH  - Organ Specificity
MH  - Primates/*physiology
MH  - Sequence Homology, Amino Acid
EDAT- 1999/05/21 00:00
MHDA- 1999/05/21 00:01
CRDT- 1999/05/21 00:00
PHST- 1999/05/21 00:00 [pubmed]
PHST- 1999/05/21 00:01 [medline]
PHST- 1999/05/21 00:00 [entrez]
AID - 10.1093/oxfordjournals.molbev.a026144 [doi]
PST - ppublish
SO  - Mol Biol Evol. 1999 May;16(5):619-26. doi: 10.1093/oxfordjournals.molbev.a026144.