PMID- 10334995
OWN - NLM
STAT- MEDLINE
DCOM- 19990618
LR  - 20191210
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5418
DP  - 1999 May 21
TI  - UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.
PG  - 1372-6
AB  - Modification of cell surface molecules with sialic acid is crucial for their
      function in many biological processes, including cell adhesion and signal
      transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc
      2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the
      sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major 
      determinant of cell surface sialylation in human hematopoietic cell lines and a
      critical regulator of the function of specific cell surface adhesion molecules.
FAU - Keppler, O T
AU  - Keppler OT
AD  - Applied Tumor Virology Program, Tumor Immunology Program, Deutsches
      Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
FAU - Hinderlich, S
AU  - Hinderlich S
FAU - Langner, J
AU  - Langner J
FAU - Schwartz-Albiez, R
AU  - Schwartz-Albiez R
FAU - Reutter, W
AU  - Reutter W
FAU - Pawlita, M
AU  - Pawlita M
LA  - eng
SI  - GENBANK/AJ238764
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (CD22 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Culture Media)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Glycoconjugates)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Lectins)
RN  - 0 (Lewis X Antigen)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Oligosaccharides)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 2)
RN  - 0 (Sialic Acids)
RN  - 0 (Sialyl Lewis X Antigen)
RN  - EC 5.1.3.- (Carbohydrate Epimerases)
RN  - EC 5.1.3.14 (UDP acetylglucosamine-2-epimerase)
RN  - EC 5.1.3.14 (wecB protein, E coli)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, B-Lymphocyte/metabolism
MH  - Carbohydrate Epimerases/genetics/metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - Cell Membrane/*metabolism
MH  - Culture Media
MH  - *Escherichia coli Proteins
MH  - Glycoconjugates/*metabolism
MH  - HL-60 Cells
MH  - Histocompatibility Antigens Class I/biosynthesis
MH  - Humans
MH  - Lectins/metabolism
MH  - Lewis X Antigen/biosynthesis
MH  - Lipopolysaccharide Receptors/biosynthesis
MH  - Oligosaccharides/biosynthesis
MH  - Rats
MH  - Sialic Acid Binding Ig-like Lectin 2
MH  - Sialic Acids/*biosynthesis
MH  - Sialyl Lewis X Antigen
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/05/21 00:00
MHDA- 1999/05/21 00:01
CRDT- 1999/05/21 00:00
PHST- 1999/05/21 00:00 [pubmed]
PHST- 1999/05/21 00:01 [medline]
PHST- 1999/05/21 00:00 [entrez]
AID - 10.1126/science.284.5418.1372 [doi]
PST - ppublish
SO  - Science. 1999 May 21;284(5418):1372-6. doi: 10.1126/science.284.5418.1372.