PMID- 10334993
OWN - NLM
STAT- MEDLINE
DCOM- 19990618
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5418
DP  - 1999 May 21
TI  - Bile acids: natural ligands for an orphan nuclear receptor.
PG  - 1365-8
AB  - Bile acids regulate the transcription of genes that control cholesterol
      homeostasis through molecular mechanisms that are poorly understood.
      Physiological concentrations of free and conjugated chenodeoxycholic acid,
      lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR;
      NR1H4), an orphan nuclear receptor. As ligands, these bile acids and their
      conjugates modulated interaction of FXR with a peptide derived from steroid
      receptor coactivator 1. These results provide evidence for a nuclear bile acid
      signaling pathway that may regulate cholesterol homeostasis.
FAU - Parks, D J
AU  - Parks DJ
AD  - Department of Molecular Biochemistry, Glaxo Wellcome Research and Development,
      Research Triangle Park NC, 27709, USA.
FAU - Blanchard, S G
AU  - Blanchard SG
FAU - Bledsoe, R K
AU  - Bledsoe RK
FAU - Chandra, G
AU  - Chandra G
FAU - Consler, T G
AU  - Consler TG
FAU - Kliewer, S A
AU  - Kliewer SA
FAU - Stimmel, J B
AU  - Stimmel JB
FAU - Willson, T M
AU  - Willson TM
FAU - Zavacki, A M
AU  - Zavacki AM
FAU - Moore, D D
AU  - Moore DD
FAU - Lehmann, J M
AU  - Lehmann JM
LA  - eng
GR  - F32 DK09793/DK/NIDDK NIH HHS/United States
GR  - R01 DK53366/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ligands)
RN  - 0 (Organic Anion Transporters, Sodium-Dependent)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Symporters)
RN  - 0 (Transcription Factors)
RN  - 005990WHZZ (Deoxycholic Acid)
RN  - 0C5V0MRU6P (farnesoid X-activated receptor)
RN  - 0GEI24LG0J (Chenodeoxycholic Acid)
RN  - 145420-23-1 (sodium-bile acid cotransporter)
RN  - 5QU0I8393U (Lithocholic Acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (NCOA1 protein, human)
RN  - EC 2.3.1.48 (Ncoa1 protein, mouse)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
CIN - Science. 1999 May 21;284(5418):1285-6. PMID: 10383308
MH  - Animals
MH  - Bile Acids and Salts/chemistry/*metabolism/pharmacology
MH  - Carrier Proteins/metabolism
MH  - Cell Line
MH  - Chenodeoxycholic Acid/*metabolism/pharmacology
MH  - Cholesterol/metabolism
MH  - DNA-Binding Proteins/chemistry/genetics/*metabolism
MH  - Deoxycholic Acid/metabolism/pharmacology
MH  - Histone Acetyltransferases
MH  - Homeostasis
MH  - Humans
MH  - Ligands
MH  - Lithocholic Acid/metabolism/pharmacology
MH  - Mice
MH  - Nuclear Receptor Coactivator 1
MH  - *Organic Anion Transporters, Sodium-Dependent
MH  - Protein Conformation
MH  - Receptors, Cytoplasmic and Nuclear/chemistry/genetics/*metabolism
MH  - Recombinant Fusion Proteins/metabolism
MH  - Signal Transduction
MH  - Structure-Activity Relationship
MH  - *Symporters
MH  - Transcription Factors/chemistry/genetics/*metabolism
MH  - Transfection
EDAT- 1999/05/21 00:00
MHDA- 1999/05/21 00:01
CRDT- 1999/05/21 00:00
PHST- 1999/05/21 00:00 [pubmed]
PHST- 1999/05/21 00:01 [medline]
PHST- 1999/05/21 00:00 [entrez]
AID - 10.1126/science.284.5418.1365 [doi]
PST - ppublish
SO  - Science. 1999 May 21;284(5418):1365-8. doi: 10.1126/science.284.5418.1365.