PMID- 10334644
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20191024
IS  - 0957-5243 (Print)
IS  - 0957-5243 (Linking)
VI  - 10
IP  - 1
DP  - 1999 Feb
TI  - Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk.
PG  - 65-70
AB  - OBJECTIVES: The human GSTTP1 gene is polymorphic with an A-->G transition in exon 
      5 causing a replacement 105 Ile-->Val in the GSTP1 protein. The two isoforms, 
      encoded by the alleles GSTP1*A and GSTP1*B, respectively, show different 
      catalytic efficiencies towards some carcinogenic epoxides. In this study we have 
      addressed the possible role of the Ile105Val GSTP1 polymorphism in lung cancer 
      susceptibility. METHODS: The polymorphic site was genotyped by RFLP in a group of 
      lung cancer patients (n = 164) and in two control groups (healthy smokers, n = 
      132; general population, n = 200). All patients and controls were Northwestern 
      Mediterranean Caucasians of the same ethnic origin. RESULTS AND CONCLUSIONS: The 
      cancer patients showed frequencies of GSTP1*A/A; GSTP1*A/B and GSTP1*B/B (50%, 
      38%, 11%, respectively) very similar to those of both control groups (healthy 
      smokers: 48%, 41%, 11%). After adjusting for age, sex and smoking status, no 
      association was found between the GSTP1*B allele and lung cancer risk (OR: 1.18; 
      95% CI: 0.67-2.07). The Ile105val GSTP1 polymorphism was also analysed in 
      combination with the GSTM1 and GSTT1 genes. The results showed that allelism at 
      GSTP1 did not increase the risk associated with the GSTM1 or GSTT1 deletions.
FAU - To-Figueras, J
AU  - To-Figueras J
AD  - Toxicology Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Spain.
FAU - Gene, M
AU  - Gene M
FAU - Gomez-Catalan, J
AU  - Gomez-Catalan J
FAU - Pique, E
AU  - Pique E
FAU - Borrego, N
AU  - Borrego N
FAU - Carrasco, J L
AU  - Carrasco JL
FAU - Ramon, J
AU  - Ramon J
FAU - Corbella, J
AU  - Corbella J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
RN  - 0 (Carcinogens)
RN  - 0 (Isoenzymes)
RN  - EC 2.5.1.18 (GSTP1 protein, human)
RN  - EC 2.5.1.18 (Glutathione S-Transferase pi)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Carcinogens/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Glutathione S-Transferase pi
MH  - Glutathione Transferase/*genetics/metabolism
MH  - Humans
MH  - Isoenzymes/*genetics/metabolism
MH  - Lung Neoplasms/etiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - 10.1023/a:1008811824890 [doi]
PST - ppublish
SO  - Cancer Causes Control. 1999 Feb;10(1):65-70. doi: 10.1023/a:1008811824890.