PMID- 10333732
OWN - NLM
STAT- MEDLINE
DCOM- 19990721
LR  - 20131121
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 21
IP  - 3
DP  - 1999 Mar
TI  - Orphan selenoproteins.
PG  - 231-7
AB  - Selenoproteins contain selenium in stoichiometric amounts. Most are synthesized
      by a process that decodes UGA codons as selenocysteine. Twelve animal
      selenoproteins have been characterized, and biochemical functions have been
      described for all but three. Two of these "orphan" selenoproteins are discussed
      in this paper. Selenoprotein P is an extracellular glycoprotein that contains
      multiple selenocysteines. It binds heparin and associates with endothelial cells.
      Two isoforms have been identified. Plasma concentration of selenoprotein P
      correlates with protection against diquat liver injury, suggesting that the
      protein protects against oxidant injury. Selenoprotein W is a small intracellular
      protein that contains one selenocysteine. It binds glutathione and has been
      suggested to function in oxidant defense. The postulated oxidant defense
      properties of these selenoproteins are consistent with the facile thiol-redox
      properties of selenocysteine. It can be predicted that more proteins will be
      discovered that take advantage of the chemical properties of selenium.
FAU - Burk, R F
AU  - Burk RF
AD  - Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt
      University School of Medicine, Nashville, TN 37232-2279, USA.
      raymond.burk@mcmail.vanderbilt.edu
FAU - Hill, K E
AU  - Hill KE
LA  - eng
GR  - DK26657/DK/NIDDK NIH HHS/United States
GR  - ES00267/ES/NIEHS NIH HHS/United States
GR  - ES02497/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Proteins)
RN  - 0 (Selenoprotein P)
RN  - 0 (Selenoprotein W)
RN  - 0 (Selenoproteins)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Molecular Sequence Data
MH  - Protein Biosynthesis
MH  - Proteins/*physiology
MH  - Selenium
MH  - Selenoprotein P
MH  - Selenoprotein W
MH  - Selenoproteins
RF  - 67
EDAT- 1999/05/20 06:00
MHDA- 2000/06/20 09:00
CRDT- 1999/05/20 06:00
PHST- 1999/05/20 06:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/05/20 06:00 [entrez]
AID - 10.1002/(SICI)1521-1878(199903)21:3<231::AID-BIES7>3.0.CO;2-D [pii]
AID - 10.1002/(SICI)1521-1878(199903)21:3<231::AID-BIES7>3.0.CO;2-D [doi]
PST - ppublish
SO  - Bioessays. 1999 Mar;21(3):231-7. doi:
      10.1002/(SICI)1521-1878(199903)21:3<231::AID-BIES7>3.0.CO;2-D.