PMID- 10332027
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 6
DP  - 1999 Jun
TI  - T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding
      protein implicated in spermatogenesis.
PG  - 959-69
AB  - RBM is an RNA-binding protein encoded on the Y chromosome in mammals and is
      expressed only in the nuclei of male germ cells. Genetic evidence from infertile 
      men implicates it in spermatogenesis, but its function is unknown. Of a number of
      potential partners for RBM identified by a yeast two-hybrid screen with testis
      cDNA, the most frequent isolates encoded a novel RNA-binding protein, termed
      T-STAR, that is closely related to SAM68, an Src-associated protein of unknown
      function. The mouse homologue was also cloned and designated etoile. It mapped to
      chromosome 15, while T-STAR mapped to the syntenic region on human chromosome 8. 
      T-STAR/etoile is expressed primarily in the testis; in rat germ cells, the
      expression of both T-STAR/etoile and SAM68 is regulated during meiosis.
      Transfection of T-STAR/etoile fused with green fluorescent protein into HeLa
      cells caused an accumulation of protein in a novel compartment of the nucleus,
      adjacent to the nucleolus but distinct from the peri-nucleolar compartment. RBM
      and other hnRNP G family members are candidate downstream targets for regulation 
      by T-STAR/ETOILE and SAM68.
FAU - Venables, J P
AU  - Venables JP
AD  - Department of Biochemistry, University of Leicester, UK.
FAU - Vernet, C
AU  - Vernet C
FAU - Chew, S L
AU  - Chew SL
FAU - Elliott, D J
AU  - Elliott DJ
FAU - Cowmeadow, R B
AU  - Cowmeadow RB
FAU - Wu, J
AU  - Wu J
FAU - Cooke, H J
AU  - Cooke HJ
FAU - Artzt, K
AU  - Artzt K
FAU - Eperon, I C
AU  - Eperon IC
LA  - eng
SI  - GENBANK/AF069681
SI  - GENBANK/AF079763
GR  - HD10668/HD/NICHD NIH HHS/United States
GR  - HD30658/HD/NICHD NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KHDRBS1 protein, human)
RN  - 0 (KHDRBS3 protein, human)
RN  - 0 (Khdrbs1 protein, mouse)
RN  - 0 (Khdrbs3 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - 3T3 Cells
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - COS Cells
MH  - Cell Nucleus/chemistry
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 8/genetics
MH  - DNA, Complementary/chemistry/genetics
MH  - DNA-Binding Proteins
MH  - Gene Expression
MH  - HeLa Cells
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Muridae
MH  - Plasmids
MH  - Protein Binding
MH  - RNA/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - RNA-Binding Proteins/*genetics/metabolism
MH  - Rats
MH  - Saccharomyces cerevisiae/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Spermatogenesis
MH  - Tissue Distribution
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - ddc117 [pii]
AID - 10.1093/hmg/8.6.959 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 Jun;8(6):959-69. doi: 10.1093/hmg/8.6.959.