PMID- 10331946
OWN - NLM
STAT- MEDLINE
DCOM- 19990706
LR  - 20170922
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 58
IP  - 1
DP  - 1999 May 15
TI  - Identification of SCML2, a second human gene homologous to the Drosophila sex
      comb on midleg (Scm): A new gene cluster on Xp22.
PG  - 65-72
AB  - We have identified a novel gene with homologies to the Drosophila Sex comb on
      midleg (Scm) gene from the short arm of the X chromosome. Scm is a member of the 
      Polycomb group (PcG) genes, which encode transcriptional repressors essential for
      appropriate development in the fly and in mammals. The newly identified
      transcript named SCML2 (sex comb on midleg like-2, HGMW-approved symbol) is
      ubiquitously expressed and encodes a protein of 700 amino acids. SCML2 maps very 
      close to the recently identified SCML1, revealing the presence of a new gene
      cluster in Xp22. The homology and map location identify SCML2 as a candidate gene
      for Xp22-linked developmental disorders, including the oral-facial-digital type I
      (OFDI) syndrome. A study of the SCML1-SCML2 cluster in primates indicates that
      the two genes are localized to the same region in Old World monkeys, New World
      monkeys, and prosimians, suggesting that the duplication event leading to the
      formation of the SCML cluster on Xp22 occurred before primate divergence.
CI  - Copyright 1999 Academic Press.
FAU - Montini, E
AU  - Montini E
AD  - Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical
      Science Park, Milan, Italy.
FAU - Buchner, G
AU  - Buchner G
FAU - Spalluto, C
AU  - Spalluto C
FAU - Andolfi, G
AU  - Andolfi G
FAU - Caruso, A
AU  - Caruso A
FAU - den Dunnen, J T
AU  - den Dunnen JT
FAU - Trump, D
AU  - Trump D
FAU - Rocchi, M
AU  - Rocchi M
FAU - Ballabio, A
AU  - Ballabio A
FAU - Franco, B
AU  - Franco B
LA  - eng
SI  - GENBANK/Y18004
GR  - E.0672/Telethon/Italy
GR  - TGM06S01/Telethon/Italy
GR  - TGM97000/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Polycomb-Group Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (SCM protein, Drosophila)
RN  - 0 (SCML1 protein, human)
RN  - 0 (SCML2 protein, human)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Cell Line
MH  - DNA/chemistry/genetics
MH  - DNA, Complementary/chemistry/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila/*genetics
MH  - *Drosophila Proteins
MH  - Female
MH  - Gene Expression
MH  - Genes/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Polycomb-Group Proteins
MH  - Primates
MH  - RNA, Messenger/genetics/metabolism
MH  - Repressor Proteins/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - *Transcription Factors
MH  - X Chromosome/genetics
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - S0888-7543(99)95755-5 [pii]
AID - 10.1006/geno.1999.5755 [doi]
PST - ppublish
SO  - Genomics. 1999 May 15;58(1):65-72. doi: 10.1006/geno.1999.5755.