PMID- 10331643
OWN - NLM
STAT- MEDLINE
DCOM- 19990809
LR  - 20190818
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 193
IP  - 1-2
DP  - 1999 Mar
TI  - Structures and activities of cyclic ADP-ribose, NAADP and their metabolic
      enzymes.
PG  - 89-98
AB  - ADP-ribosyl cyclase and CD38 are multi-functional enzymes involved in calcium
      signaling. Both can cyclize NAD and its guanine analog, NGD, at two different
      sites of the purine ring, N1 and N7, respectively, to produce cyclic ADP-ribose
      (cADPR) and cyclic GDP-ribose, a fluorescent but inactive analog. Both enzymes
      can also catalyze the exchange of the nicotinamide group of NADP with nicotinic
      acid, producing yet another potent activator of Ca2+ mobilization, nicotinic acid
      adenine dinucleotide phosphate (NAADP). The Ca2+ release mechanism activated by
      NAADP is totally independent of cADPR and inositol trisphosphate indicating it is
      a novel and hitherto unknown Ca2+ signaling pathway. This article summarizes the 
      current results on the structures and activities of cADPR, NAADP and the enzymes 
      that catalyze their syntheses. A comprehensive model accounting for the novel
      multi-functionality of ADP-ribosyl cyclase and CD38 is presented.
FAU - Lee, H C
AU  - Lee HC
AD  - Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
FAU - Munshi, C
AU  - Munshi C
FAU - Graeff, R
AU  - Graeff R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 20762-30-5 (Adenosine Diphosphate Ribose)
RN  - 53-59-8 (NADP)
RN  - 5502-96-5 (NAADP)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (NAD+ Nucleosidase)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - ADP-ribosyl Cyclase
MH  - ADP-ribosyl Cyclase 1
MH  - Adenosine Diphosphate Ribose/analogs & derivatives/*chemistry/*metabolism
MH  - *Antigens, CD
MH  - Antigens, Differentiation/metabolism
MH  - Calcium/metabolism
MH  - Catalysis
MH  - Dose-Response Relationship, Drug
MH  - Models, Chemical
MH  - Models, Genetic
MH  - Models, Molecular
MH  - NAD+ Nucleosidase/metabolism
MH  - NADP/*analogs & derivatives/chemistry/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Structure-Activity Relationship
MH  - Time Factors
RF  - 61
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - 10.1007/978-1-4419-8740-2_13 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 1999 Mar;193(1-2):89-98. doi: 10.1007/978-1-4419-8740-2_13.