PMID- 10330501
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190909
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 81
IP  - 1-2
DP  - 1999 Mar
TI  - Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin.
PG  - 205-8
AB  - The T-box gene family has been conserved throughout metazoan evolution. The genes
      code for putative transcription factors which share a uniquely defining DNA
      binding domain, known as the T-box ([Bollag et al., 1994]). They are implicated
      in the control of diverse developmental processes by their highly specific
      expression patterns throughout gastrulation and organogenesis in mouse and other 
      species ([Chapman et al., 1996]) ([Gibson-Brown et al., 1998]), and by mutations 
      in T-box genes that have profound developmental effects ([Papaioannou, 1997];
      [Chapman and Papaioannou, 1998]; [Papaioannou and Silver, 1998]). In this report,
      we describe the mapping and expression pattern of the mouse ortholog of a gene,
      Eomesodermin, first identified in Xenopus ([Ryan et al., 1996]). The mouse gene
      was previously reported ([Wattler et al., 1998]) under the name MmEomes. The gene
      maps to mouse chromosome 9 in a region syntenic with human chromosome 3p. Mouse
      eomesodermin is expressed in the trophoblast of the blastocyst and in its
      derivative, the chorionic ectoderm. At gastrulation, eomesodermin is expressed in
      the primitive streak and embryonic mesoderm as well, but this expression
      disappears prior to the end of gastrulation. Later, eomesodermin is expressed in 
      the developing forebrain, in a pattern largely overlapping a closely related
      T-box gene, Tbr1 ([Bulfone et al., 1995]), and is also seen in a localized area
      of each limb.
FAU - Hancock, S N
AU  - Hancock SN
AD  - Department of Genetics and Development, College of Physicians and Surgeons of
      Columbia University, 701 West 168th Street, New York, NY 10032, USA.
FAU - Agulnik, S I
AU  - Agulnik SI
FAU - Silver, L M
AU  - Silver LM
FAU - Papaioannou, V E
AU  - Papaioannou VE
LA  - eng
GR  - HD 20275/HD/NICHD NIH HHS/United States
GR  - HD33082/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (EOMES protein, Xenopus)
RN  - 0 (Eomes protein, mouse)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Xenopus Proteins)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Crosses, Genetic
MH  - Databases, Factual
MH  - Embryo, Mammalian/metabolism
MH  - Embryo, Nonmammalian
MH  - In Situ Hybridization
MH  - Mice
MH  - Models, Genetic
MH  - *T-Box Domain Proteins
MH  - Time Factors
MH  - Tissue Distribution
MH  - Transcription Factors/genetics/*metabolism
MH  - Xenopus/*embryology
MH  - *Xenopus Proteins
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - S0925-4773(98)00244-5 [pii]
AID - 10.1016/s0925-4773(98)00244-5 [doi]
PST - ppublish
SO  - Mech Dev. 1999 Mar;81(1-2):205-8. doi: 10.1016/s0925-4773(98)00244-5.