PMID- 10330459
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20171116
IS  - 0022-1554 (Print)
IS  - 0022-1554 (Linking)
VI  - 47
IP  - 6
DP  - 1999 Jun
TI  - HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in
      the developing mouse lung.
PG  - 823-32
AB  - HNF-3/forkhead homologue-4 (HFH-4), a transcription factor of the
      winged-helix/forkhead family, was detected by immunohistochemistry in tissue of
      the developing mouse. HFH-4 protein was present in epithelial cells of the lung, 
      trachea, oviduct, and embryonic esophagus, and in ependymal cells lining the
      spinal column and ventricles of the brain. In lung, trachea, and nose, HFH-4 was 
      expressed in a distinct subset of epithelial cells that also expressed
      beta-tubulin IV, a ciliated cell marker. Cellular sites of HFH-4 and beta-tubulin
      IV expression were distinct from that of Clara cell secretory protein (CCSP),
      which was detected in nonciliated epithelial cells in the conducting airway of
      the lung. HFH-4 and beta-tubulin IV, but not CCSP, were detected in the
      respiratory epithelium of thyroid transcription factor-1 (TTF-1) gene-targeted
      mice. The presence of HFH-4 and beta-tubulin IV in TTF-1 gene-targeted mice
      demonstrates that differentiation of ciliated epithelium does not require TTF-1. 
      Co-localization of HFH-4 and beta-tubulin IV staining in various tissues during
      mouse development supports a role for HFH-4 in the differentiation of ciliated
      cell lineages.
FAU - Tichelaar, J W
AU  - Tichelaar JW
AD  - Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati,
      Ohio, USA.
FAU - Wert, S E
AU  - Wert SE
FAU - Costa, R H
AU  - Costa RH
FAU - Kimura, S
AU  - Kimura S
FAU - Whitsett, J A
AU  - Whitsett JA
LA  - eng
GR  - HL 41496/HL/NHLBI NIH HHS/United States
GR  - HL 56387/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Histochem Cytochem
JT  - The journal of histochemistry and cytochemistry : official journal of the
      Histochemistry Society
JID - 9815334
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hepatocyte Nuclear Factor 4)
RN  - 0 (Nkx2-1 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Scgb1a1 protein, mouse)
RN  - 0 (Tcfl4 protein, mouse)
RN  - 0 (Thyroid Nuclear Factor 1)
RN  - 0 (Transcription Factors)
RN  - 0 (Tubulin)
RN  - 9060-09-7 (Uteroglobin)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - DNA-Binding Proteins/biosynthesis/metabolism
MH  - Epithelial Cells/metabolism
MH  - Hepatocyte Nuclear Factor 4
MH  - Immunohistochemistry
MH  - Lung/*embryology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Nuclear Proteins/biosynthesis/genetics
MH  - Phosphoproteins/*biosynthesis/metabolism
MH  - Protein Biosynthesis
MH  - Thyroid Nuclear Factor 1
MH  - Tissue Distribution
MH  - Transcription Factors/*biosynthesis/genetics/metabolism
MH  - Tubulin/biosynthesis/metabolism
MH  - *Uteroglobin
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - 10.1177/002215549904700612 [doi]
PST - ppublish
SO  - J Histochem Cytochem. 1999 Jun;47(6):823-32. doi: 10.1177/002215549904700612.