PMID- 10330454
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20170214
IS  - 0022-1554 (Print)
IS  - 0022-1554 (Linking)
VI  - 47
IP  - 6
DP  - 1999 Jun
TI  - Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human 
      lectin secreted into bronchus/alveolus and bile.
PG  - 777-86
AB  - Hakata antigen was first reported as a serum protein that reacted with an
      autoantibody from patients with systemic lupus erythematosus. Recently, it has
      been found that Hakata antigen is a new member of the ficolin/opsonin p35 family,
      which is a distinct lectin family, on the basis of homology of structures and the
      common characteristic of possessing lectin activity. In this study we analyzed
      the tissue distribution of Hakata antigen. Hakata antigen mRNA and protein were
      generated in the lung and liver. In the lung, Hakata antigen was produced by both
      ciliated bronchial epithelial cells and Type II alveolar epithelial cells and was
      secreted into the bronchus and alveolus. In the liver, Hakata antigen was
      produced by bile duct epithelial cells and hepatocytes and was also secreted into
      the bile duct. These results demonstrate that Hakata antigen is a unique lectin
      protein that exists not only in serum but also in bronchus/alveolus and bile, and
      indicate that Hakata antigen plays a role in bronchus/alveolus and bile under
      physiological conditions.
FAU - Akaiwa, M
AU  - Akaiwa M
AD  - Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine,
      Kyushu University, Fukuoka, Japan.
FAU - Yae, Y
AU  - Yae Y
FAU - Sugimoto, R
AU  - Sugimoto R
FAU - Suzuki, S O
AU  - Suzuki SO
FAU - Iwaki, T
AU  - Iwaki T
FAU - Izuhara, K
AU  - Izuhara K
FAU - Hamasaki, N
AU  - Hamasaki N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Histochem Cytochem
JT  - The journal of histochemistry and cytochemistry : official journal of the
      Histochemistry Society
JID - 9815334
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (FCN3 protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Lectins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Bile Ducts/*metabolism
MH  - Bronchi/metabolism
MH  - Glycoproteins/*biosynthesis/genetics/immunology/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Lectins
MH  - Liver/metabolism
MH  - Lung/*metabolism
MH  - Pulmonary Alveoli/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Tissue Distribution
EDAT- 1999/05/20 00:00
MHDA- 1999/05/20 00:01
CRDT- 1999/05/20 00:00
PHST- 1999/05/20 00:00 [pubmed]
PHST- 1999/05/20 00:01 [medline]
PHST- 1999/05/20 00:00 [entrez]
AID - 10.1177/002215549904700607 [doi]
PST - ppublish
SO  - J Histochem Cytochem. 1999 Jun;47(6):777-86. doi: 10.1177/002215549904700607.