PMID- 10330188
OWN - NLM
STAT- MEDLINE
DCOM- 19990617
LR  - 20210526
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 19
IP  - 6
DP  - 1999 Jun
TI  - FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors.
PG  - 4495-502
AB  - Members of the GATA family of zinc finger transcription factors have been shown
      to play important roles in the control of gene expression in a variety of cell
      types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages 
      and are required for proliferation and differentiation of multiple hematopoietic 
      cell types, whereas GATA-4, -5, and -6 are expressed in the heart, where they
      activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype
      zinc finger protein that interacts with GATA-1 and serves as a cofactor for
      GATA-1-mediated transcription. FOG is coexpressed with GATA-1 in developing
      erythroid and megakaryocyte cell lineages and cooperates with GATA-1 to control
      erythropoiesis. We describe a novel FOG-related factor, FOG-2, that is expressed 
      predominantly in the developing and adult heart, brain, and testis. FOG-2
      interacts with GATA factors, and interaction of GATA-4 and FOG-2 results in
      either synergistic activation or repression of GATA-dependent cardiac promoters, 
      depending on the specific promoter and the cell type in which they are tested.
      The properties of FOG-2 suggest its involvement in the control of cardiac and
      neural gene expression by GATA transcription factors.
FAU - Lu, J R
AU  - Lu JR
AD  - Departments of Molecular Biology and Oncology, University of Texas Southwestern
      Medical Center at Dallas, Dallas, Texas 75235-9148, USA.
FAU - McKinsey, T A
AU  - McKinsey TA
FAU - Xu, H
AU  - Xu H
FAU - Wang, D Z
AU  - Wang DZ
FAU - Richardson, J A
AU  - Richardson JA
FAU - Olson, E N
AU  - Olson EN
LA  - eng
SI  - GENBANK/AF125166
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GATA4 Transcription Factor)
RN  - 0 (Transcription Factors)
RN  - 0 (ZFPM2 protein, human)
RN  - 0 (Zfpm2 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/*metabolism
MH  - COS Cells
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/analysis/*metabolism/*physiology
MH  - Databases, Factual
MH  - Embryo, Mammalian/anatomy & histology
MH  - Expressed Sequence Tags
MH  - GATA4 Transcription Factor
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Myocardium/*metabolism
MH  - Promoter Regions, Genetic
MH  - Rats
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Testis/metabolism
MH  - Tissue Distribution
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
MH  - Transfection
MH  - Zinc Fingers/genetics
PMC - PMC104407
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - 10.1128/MCB.19.6.4495 [doi]
PST - ppublish
SO  - Mol Cell Biol. 1999 Jun;19(6):4495-502. doi: 10.1128/MCB.19.6.4495.