PMID- 10329693
OWN - NLM
STAT- MEDLINE
DCOM- 19990709
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 21
DP  - 1999 May 21
TI  - Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human 
      heart.
PG  - 14926-35
AB  - A novel cDNA has been identified from human heart that encodes an unusual mosaic 
      serine protease, designated corin. Corin has a predicted structure of a type II
      transmembrane protein and contains two frizzled-like cysteine-rich motifs, seven 
      low density lipoprotein receptor repeats, a macrophage scavenger receptor-like
      domain, and a trypsin-like protease domain in the extracellular region. Northern 
      analysis showed that corin mRNA was highly expressed in the human heart. In mice,
      corin mRNA was detected by in situ hybridization in the cardiac myocytes of the
      embryonic heart as early as embryonic day (E) 9.5. By E11.5-13.5, corin mRNA was 
      most abundant in the primary atrial septum and the trabecular ventricular
      compartment. Expression in the heart was maintained through the adult. In
      addition, mouse corin mRNA was also detected in the prehypertrophic chrondrocytes
      in developing bones. By fluorescent in situ hybridization analysis, the human
      corin gene was mapped to 4p12-13 where a congenital heart disease locus, total
      anomalous pulmonary venous return, had been previously localized. The unique
      domain structure and specific embryonic expression pattern suggest that corin may
      have a function in cell differentiation during development. The chromosomal
      localization of the human corin gene makes it an attractive candidate gene for
      total anomalous pulmonary venous return.
FAU - Yan, W
AU  - Yan W
AD  - Departments of Cardiovascular Research and Biophysics, Berlex Biosciences,
      Richmond, California 94804, USA.
FAU - Sheng, N
AU  - Sheng N
FAU - Seto, M
AU  - Seto M
FAU - Morser, J
AU  - Morser J
FAU - Wu, Q
AU  - Wu Q
LA  - eng
SI  - GENBANK/AF133845
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.21.- (CORIN protein, human)
RN  - EC 3.4.21.- (Corin protein, mouse)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Myocardium/*enzymology
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/biosynthesis
MH  - Serine Endopeptidases/*genetics/isolation & purification
MH  - Tumor Cells, Cultured
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - 10.1074/jbc.274.21.14926 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 May 21;274(21):14926-35. doi: 10.1074/jbc.274.21.14926.