PMID- 10329646
OWN - NLM
STAT- MEDLINE
DCOM- 19990709
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 21
DP  - 1999 May 21
TI  - Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
PG  - 14560-7
AB  - Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain
      caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, 
      a protein with an NH2-terminal CARD-linked to a nucleotide-binding domain and a
      COOH-terminal segment with multiple leucine-rich repeats, was identified. Nod-1
      was found to bind to multiple caspases with long prodomains, but specifically
      activated caspase-9 and promoted caspase-9-induced apoptosis. As reported for
      Apaf-1, Nod1 required both the CARD and P-loop for function. Unlike Apaf-1, Nod1 
      induced activation of nuclear factor-kappa-B (NF-kappaB) and bound RICK, a
      CARD-containing kinase that also induces NF-kappaB activation. Nod1 mutants
      inhibited NF-kappaB activity induced by RICK, but not that resulting from tumor
      necrosis factor-alpha stimulation. Thus, Nod1 is a leucine-rich repeat-containing
      Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation
      pathways.
FAU - Inohara, N
AU  - Inohara N
AD  - Department of Pathology and Comprehensive Cancer Center, The University of
      Michigan Medical School, Ann Arbor, Michigan 48109, USA.
FAU - Koseki, T
AU  - Koseki T
FAU - del Peso, L
AU  - del Peso L
FAU - Hu, Y
AU  - Hu Y
FAU - Yee, C
AU  - Yee C
FAU - Chen, S
AU  - Chen S
FAU - Carrio, R
AU  - Carrio R
FAU - Merino, J
AU  - Merino J
FAU - Liu, D
AU  - Liu D
FAU - Ni, J
AU  - Ni J
FAU - Nunez, G
AU  - Nunez G
LA  - eng
SI  - GENBANK/AF113925
SI  - GENBANK/AF149773
SI  - GENBANK/AF149774
SI  - GENBANK/AH007965
GR  - K04 CA64421/CA/NCI NIH HHS/United States
GR  - R01 CA64556/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (APAF1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Apoptotic Protease-Activating Factor 1)
RN  - 0 (Carrier Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (NOD1 protein, human)
RN  - 0 (Nod1 Signaling Adaptor Protein)
RN  - 0 (Proteins)
RN  - EC 3.4.22.- (CASP9 protein, human)
RN  - EC 3.4.22.- (Caspase 9)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - *Apoptosis
MH  - Apoptotic Protease-Activating Factor 1
MH  - Carrier Proteins/genetics/isolation & purification/*physiology
MH  - Caspase 9
MH  - Caspases/*physiology
MH  - Chromosome Mapping
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mutation
MH  - NF-kappa B/*physiology
MH  - Nod1 Signaling Adaptor Protein
MH  - Proteins
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - 10.1074/jbc.274.21.14560 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 May 21;274(21):14560-7. doi: 10.1074/jbc.274.21.14560.