PMID- 10329612
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20181201
IS  - 0002-9440 (Print)
IS  - 0002-9440 (Linking)
VI  - 154
IP  - 5
DP  - 1999 May
TI  - HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is 
      expressed in nervous system as well as in intestine and pancreas of the
      postimplantation mouse embryo.
PG  - 1601-10
AB  - We originally isolated the HIP/PAP gene in a differential screen of a human
      hepatocellular carcinoma cDNA library. This gene is expressed at high levels in
      25% of primary liver cancers but not in nontumorous liver. HIP/PAP belongs to the
      family of C-type lectins and acts as an adhesion molecule for hepatocytes. In
      normal adult human tissues, HIP/PAP expression is found in pancreas (exocrine and
      endocrine cells) and small intestine (Paneth and neuroendocrine cells). In order 
      to gain insight into the possible role of HIP/PAP in vivo, we have investigated
      the pattern of HIP/PAP expression in the developing postimplantation mouse embryo
      by in situ hybridization. Detailed analysis of developing mouse embryos revealed 
      that HIP/PAP gene exhibits a restricted expression pattern during development.
      Thus, HIP/PAP transcripts are first observed within the nervous system from day
      14.5 onwards in trigeminal ganglia, dorsal root ganglia, and spinal cord where it
      appears to be an early specific marker of a subpopulation of motor neurons. At
      laster stages, HIP/PAP transcripts were detected in intestine and pancreas at day
      16.5 but not in embryonic liver. This highly restricted expression pattern
      suggests that HIP/PAP might participate in neuronal as well as intestinal and
      pancreatic cell development.
FAU - Lasserre, C
AU  - Lasserre C
AD  - Unite INSERM 370, CHU Necker and INSERM U 257, Institut Cochin de Genetique
      Moleculaire, Paris, France. lasserre@necker.fr
FAU - Colnot, C
AU  - Colnot C
FAU - Brechot, C
AU  - Brechot C
FAU - Poirier, F
AU  - Poirier F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Lectins)
RN  - 0 (Pancreatitis-Associated Proteins)
RN  - 0 (REG3A protein, human)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Carcinoma, Hepatocellular/*genetics
MH  - Embryonic Development
MH  - Embryonic and Fetal Development/physiology
MH  - Female
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Gene Expression Regulation, Neoplastic/*physiology
MH  - Genetic Code
MH  - Humans
MH  - In Situ Hybridization
MH  - Intestinal Mucosa/*metabolism
MH  - Lectins/genetics
MH  - Liver Neoplasms/*genetics
MH  - Mice
MH  - Pancreas/*metabolism
MH  - Pancreatitis-Associated Proteins
MH  - Pregnancy
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC1866603
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S0002-9440(10)65413-2 [pii]
AID - 10.1016/S0002-9440(10)65413-2 [doi]
PST - ppublish
SO  - Am J Pathol. 1999 May;154(5):1601-10. doi: 10.1016/S0002-9440(10)65413-2.