PMID- 10329540
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20191210
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 257
IP  - 2
DP  - 1999 May 10
TI  - Identification of human and mouse homologs of the MC51L-53L-54L family of
      secreted glycoproteins encoded by the Molluscum contagiosum poxvirus.
PG  - 297-302
AB  - Molluscum contagiosum virus (MCV) is a human poxvirus that produces small, benign
      skin tumors primarily in young children and encodes proteins that modulate the
      host immune response. The MC51L, MC53L, and MC54L open reading frames of MCV have
      significant amino acid sequence similarities and related proteins are encoded by 
      other poxviruses. These three MCV genes were individually expressed in mammalian 
      cells as glycosylated and secreted proteins. A database search detected partial
      sequences of homologous human and mouse cDNAs; determination of the complete
      sequences confirmed the homology and indicated potential signal peptides and
      N-glycosylation sites as well as a pattern of cysteines that are conserved in the
      viral proteins. The human gene, which was mapped to chromosome 11q13, was highly 
      expressed in spleen and lymph nodes, suggesting an immune modulatory role. The
      latter finding is consistent with a recent report (Novick et al., 1999, Immunity 
      10, 127-136) that the human protein binds IL-18, suggesting an anti-inflammatory 
      role for the poxvirus homologs.
FAU - Xiang, Y
AU  - Xiang Y
AD  - Laboratory of Viral Diseases, National Institute of Allergy and Infectious
      Diseases, Bethesda, Maryland 20892-0445, USA.
FAU - Moss, B
AU  - Moss B
LA  - eng
SI  - GENBANK/AF122906
SI  - GENBANK/AF122907
SI  - GENBANK/AF122908
PT  - Journal Article
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA, Complementary)
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - DNA, Complementary
MH  - Gene Expression
MH  - Glycoproteins/*genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Molluscum contagiosum virus/*genetics
MH  - Open Reading Frames
MH  - Tissue Distribution
MH  - Viral Proteins/*genetics
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S0042-6822(99)99676-9 [pii]
AID - 10.1006/viro.1999.9676 [doi]
PST - ppublish
SO  - Virology. 1999 May 10;257(2):297-302. doi: 10.1006/viro.1999.9676.