PMID- 10329396
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20041118
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 258
IP  - 2
DP  - 1999 May 10
TI  - Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with 
      Alzheimer's beta-amyloid precursor protein.
PG  - 385-9
AB  - Recently we cloned the cDNA encoding human Fe65L2, which interacts with
      Alzheimer's beta-amyloid precursor protein (APP). The protein has one WW domain
      and two PID elements (Neurosci. Lett. (1999) 261, 143-146.). Here, we report the 
      entire genome structure and the chromosomal mapping of the Fe65L2 gene. The gene 
      is composed of thirteen coding exons distributed over 6 kb and the genomic
      organization is similar to another Fe65 member, Fe65 gene. Two transcription
      start sites of the gene were found in a CpG island by primer extension analysis. 
      Radiation hybrid mapping revealed that the Fe65L2 gene is on chromosome 5 between
      markers SHGC-9824 (D5S2374) and SHGC-8489 (D5S2569). Characterization of the
      Fe65L2 gene structure will be useful in the linkage analysis and search for
      mutations in the Fe65L2 gene in patients with Alzheimer's disease.
CI  - Copyright 1999 Academic Press.
FAU - Tanahashi, H
AU  - Tanahashi H
AD  - Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 
      4-1-1 Ogawahigashi, Kodaira, 187-8502, Japan. tanahashi@ncnaxp.ncnp.go.jp
FAU - Tabira, T
AU  - Tabira T
LA  - eng
SI  - GENBANK/AB024745
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (APBB3 protein, human)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Phosphoproteins)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alzheimer Disease/*genetics
MH  - Amyloid beta-Protein Precursor/*genetics
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 5
MH  - DNA
MH  - Exons
MH  - *Genome
MH  - Humans
MH  - Introns
MH  - Molecular Sequence Data
MH  - Phosphoproteins/*genetics
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S0006-291X(99)90639-3 [pii]
AID - 10.1006/bbrc.1999.0639 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 May 10;258(2):385-9. doi:
      10.1006/bbrc.1999.0639.