PMID- 10329394 OWN - NLM STAT- MEDLINE DCOM- 19990615 LR - 20061115 IS - 0006-291X (Print) IS - 0006-291X (Linking) VI - 258 IP - 2 DP - 1999 May 10 TI - A novel serine protease overexpressed in the hair follicles of nude mice. PG - 374-8 AB - We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed. CI - Copyright 1999 Academic Press. FAU - Meier, N AU - Meier N AD - Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, Stuebeweg 51, Freiburg, D-79108, Germany. FAU - Dear, T N AU - Dear TN FAU - Boehm, T AU - Boehm T LA - eng SI - GENBANK/Y18723 PT - Journal Article PL - United States TA - Biochem Biophys Res Commun JT - Biochemical and biophysical research communications JID - 0372516 RN - 0 (DNA, Complementary) RN - EC 3.4.21.- (Kallikreins) RN - EC 3.4.21.- (Prss18 protein, mouse) RN - EC 3.4.21.- (Serine Endopeptidases) SB - IM MH - Amino Acid Sequence MH - Animals MH - Base Sequence MH - DNA, Complementary MH - Gene Expression MH - Hair/*enzymology MH - *Kallikreins MH - Mice MH - Mice, Nude MH - Molecular Sequence Data MH - Serine Endopeptidases/*genetics/metabolism MH - Skin/metabolism EDAT- 1999/05/18 00:00 MHDA- 1999/05/18 00:01 CRDT- 1999/05/18 00:00 PHST- 1999/05/18 00:00 [pubmed] PHST- 1999/05/18 00:01 [medline] PHST- 1999/05/18 00:00 [entrez] AID - S0006-291X(99)90600-9 [pii] AID - 10.1006/bbrc.1999.0600 [doi] PST - ppublish SO - Biochem Biophys Res Commun. 1999 May 10;258(2):374-8. doi: 10.1006/bbrc.1999.0600.