PMID- 10329375
OWN - NLM
STAT- MEDLINE
DCOM- 19990615
LR  - 20091119
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 258
IP  - 2
DP  - 1999 May 10
TI  - Identification of a novel kinase-like gene induced during neuronal cell death.
PG  - 260-4
AB  - When deprived of neurotrophic factors, neuronal cells undergo a form of
      programmed cell death that involves a cascade of gene expression. To better
      understand this cascade, we screened the genes induced during programmed cell
      death evoked in neuronal PC6-3 cells by NGF-depletion and discovered a novel
      gene, NIPK (Neuronal cell death Inducible Putative Kinase), that contains a
      kinase-like domain. Expression of NIPK was also induced in cultured sympathetic
      neurons by NGF deprivation and in cortical neurons exposed to the Ca2+ ionophore,
      A23187. In contrast, NIPK was not induced during non-neuronal cell death evoked
      by serum or growth factor deprivation, or by treatment with methyl
      methanesulfonate, an agent that causes cell death by damaging DNA. Taken
      together, these findings suggest that NIPK is involved in programmed cell death
      via a pathway that is present in neurons but is absent in non-neurons.
CI  - Copyright 1999 Academic Press.
FAU - Mayumi-Matsuda, K
AU  - Mayumi-Matsuda K
AD  - Shionogi Institute for Medical Science, 5-1, Mishima 2-chome, Settsu-shi, Osaka, 
      566-0022, Japan.
FAU - Kojima, S
AU  - Kojima S
FAU - Suzuki, H
AU  - Suzuki H
FAU - Sakata, T
AU  - Sakata T
LA  - eng
SI  - GENBANK/AB020967
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA, Complementary)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.- (neuronal cell death inducible putative kinase)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Apoptosis
MH  - Cell Line
MH  - DNA, Complementary
MH  - Gene Expression Regulation, Enzymologic
MH  - Molecular Sequence Data
MH  - Neurons/*cytology
MH  - Protein Kinases/chemistry/*genetics
MH  - Sequence Homology, Amino Acid
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S0006-291X(99)90576-4 [pii]
AID - 10.1006/bbrc.1999.0576 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 May 10;258(2):260-4. doi:
      10.1006/bbrc.1999.0576.