PMID- 10328938
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20061115
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 156
IP  - 2
DP  - 1999 Apr
TI  - Multiple cadherin mRNA expression and developmental regulation of a novel
      cadherin in the developing mouse eye.
PG  - 316-25
AB  - Cadherins form a large family of transmembrane glycoproteins whose members
      include the classical cadherins, the desmosomal cadherins, and the
      protocadherins. The classical cadherins mediate homophilic cell-cell adhesion and
      are key regulators of many morphogenetic processes. More than a dozen classical
      cadherins are expressed in both the developing and the mature central nervous
      system. Although individual cadherins have been identified in the retina of
      various species, we wished to determine the range of cadherins expressed at
      distinct developmental stages in the mouse retina. Using a PCR-based cloning
      strategy, we detected 10 different classical cadherin mRNAs of both type I and
      type II subtypes. The most abundant cDNA was that encoding the type II cadherin, 
      Cadherin-11. The other type II cadherins detected were VE- and T2-cadherin and
      Cadherin-6 and -12. Four type I cadherins, N-, R-, P-, and E-cadherin, were also 
      present. One cadherin cDNA encoded a novel cadherin, called EY-cadherin for
      cloned from eye. EY-cadherin is most closely related to human Cadherin-14 (93%
      identical). EY-cadherin mRNA was detected in the adult mouse eye, brain, and
      testis with a 20-fold increase in expression levels in the embryonic head from
      E11 to E19 and a 50-fold increase in expression levels in the postnatal eye from 
      PN1 to PN16. Multiple cadherin gene expression is consistent with the hypothesis 
      that different cadherins regulate morphogenetic processes, such as neuronal
      migration and lamination, and determine the specific interneuronal connections
      found in the mature retina.
CI  - Copyright 1999 Academic Press.
FAU - Faulkner-Jones, B E
AU  - Faulkner-Jones BE
AD  - Department of Anatomy and Cell Biology, Howard Florey Institute, Parkville,
      Victoria, 3052, Australia.
FAU - Godinho, L N
AU  - Godinho LN
FAU - Tan, S S
AU  - Tan SS
LA  - eng
SI  - GENBANK/AF068258
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Cadherins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Eye Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cadherins/biosynthesis/classification/*genetics
MH  - Cell Adhesion
MH  - DNA, Complementary/genetics
MH  - Eye/*embryology/growth & development
MH  - Eye Proteins/biosynthesis/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Isoforms/biosynthesis/*genetics
MH  - RNA, Messenger/*biosynthesis/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
EDAT- 1999/05/18 00:00
MHDA- 1999/05/18 00:01
CRDT- 1999/05/18 00:00
PHST- 1999/05/18 00:00 [pubmed]
PHST- 1999/05/18 00:01 [medline]
PHST- 1999/05/18 00:00 [entrez]
AID - S0014-4886(99)97026-7 [pii]
AID - 10.1006/exnr.1999.7026 [doi]
PST - ppublish
SO  - Exp Neurol. 1999 Apr;156(2):316-25. doi: 10.1006/exnr.1999.7026.