PMID- 10325223
OWN - NLM
STAT- MEDLINE
DCOM- 19990608
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5417
DP  - 1999 May 14
TI  - Control of hippocampal morphogenesis and neuronal differentiation by the LIM
      homeobox gene Lhx5.
PG  - 1155-8
AB  - The mammalian hippocampus contains the neural circuitry that is crucial for
      cognitive functions such as learning and memory. The development of such
      circuitry is dependent on the generation and correct placement of the appropriate
      number and types of neurons. Mice lacking function of the LIM homeobox gene Lhx5 
      showed a defect in hippocampus development. Hippocampal neural precursor cells
      were specified and proliferated, but many of them failed to either exit the cell 
      cycle or to differentiate and migrate properly. Lhx5 is therefore essential for
      the regulation of precursor cell proliferation and the control of neuronal
      differentiation and migration during hippocampal development.
FAU - Zhao, Y
AU  - Zhao Y
AD  - Laboratory of Mammalian Genes and Development, National Institute of Child Health
      and Human Development, Bethesda, MD 20892, USA.
FAU - Sheng, H Z
AU  - Sheng HZ
FAU - Amini, R
AU  - Amini R
FAU - Grinberg, A
AU  - Grinberg A
FAU - Lee, E
AU  - Lee E
FAU - Huang, S
AU  - Huang S
FAU - Taira, M
AU  - Taira M
FAU - Westphal, H
AU  - Westphal H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Homeodomain Proteins)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Lhx5 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Body Patterning
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Movement
MH  - Crosses, Genetic
MH  - Dentate Gyrus/cytology/embryology
MH  - Female
MH  - Gene Deletion
MH  - Gene Expression
MH  - *Genes, Homeobox
MH  - Hippocampus/*cytology/*embryology
MH  - Homeodomain Proteins/*genetics/physiology
MH  - Interneurons/cytology
MH  - LIM-Homeodomain Proteins
MH  - Male
MH  - Mice
MH  - Morphogenesis
MH  - Nerve Tissue Proteins/*genetics/physiology
MH  - Neuroglia/cytology
MH  - Neurons/*cytology
MH  - Pyramidal Cells/cytology
MH  - Stem Cells/*cytology
MH  - Transcription Factors
EDAT- 1999/05/15 00:00
MHDA- 1999/05/15 00:01
CRDT- 1999/05/15 00:00
PHST- 1999/05/15 00:00 [pubmed]
PHST- 1999/05/15 00:01 [medline]
PHST- 1999/05/15 00:00 [entrez]
AID - 10.1126/science.284.5417.1155 [doi]
PST - ppublish
SO  - Science. 1999 May 14;284(5417):1155-8. doi: 10.1126/science.284.5417.1155.