PMID- 10321733
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20091119
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 12
DP  - 1999 Mar 25
TI  - RBP1 induces growth arrest by repression of E2F-dependent transcription.
PG  - 2091-100
AB  - Growth arrest and cell cycle progression are regulated by the retinoblastoma
      tumour suppressor pRB and related proteins p130 and p107 that bind to and inhibit
      the E2F family of transcription factors. Although the precise mechanism of this
      inhibition remains to be established, previous studies indicated the presence of 
      transcriptional repression activity in the 'pocket' of RB family members. We show
      here that RBP1, a known pRB pocket-binding protein, possesses transcriptional
      repression activity and associates with p130-E2F and pRB-E2F complexes
      specifically during growth arrest. Overexpression of RBP1 both inhibited
      E2F-dependent gene expression and suppressed cell growth. Thus repression of
      E2F-dependent transcription by RBP1 via RB family members may play a central role
      in inducing growth arrest.
FAU - Lai, A
AU  - Lai A
AD  - Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
FAU - Marcellus, R C
AU  - Marcellus RC
FAU - Corbeil, H B
AU  - Corbeil HB
FAU - Branton, P E
AU  - Branton PE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (E2F Transcription Factors)
RN  - 0 (Repressor Proteins)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Retinoblastoma-Binding Protein 1)
RN  - 0 (Transcription Factor DP1)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cell Cycle/*genetics
MH  - *Cell Cycle Proteins
MH  - Cricetinae
MH  - *DNA-Binding Proteins
MH  - E2F Transcription Factors
MH  - Gene Expression Regulation
MH  - Humans
MH  - Protein Binding
MH  - Repressor Proteins/*metabolism
MH  - Retinoblastoma Protein/genetics/*metabolism
MH  - Retinoblastoma-Binding Protein 1
MH  - Transcription Factor DP1
MH  - Transcription Factors/*metabolism
MH  - Transcription, Genetic
EDAT- 1999/05/13 00:00
MHDA- 1999/05/13 00:01
CRDT- 1999/05/13 00:00
PHST- 1999/05/13 00:00 [pubmed]
PHST- 1999/05/13 00:01 [medline]
PHST- 1999/05/13 00:00 [entrez]
AID - 10.1038/sj.onc.1202520 [doi]
PST - ppublish
SO  - Oncogene. 1999 Mar 25;18(12):2091-100. doi: 10.1038/sj.onc.1202520.