PMID- 10321732
OWN - NLM
STAT- MEDLINE
DCOM- 19990603
LR  - 20181201
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 12
DP  - 1999 Mar 25
TI  - JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation.
PG  - 2085-90
AB  - 1q21 is frequently involved in different types of translocation in many types of 
      cancers. Jumping translocation (JT) is an unbalanced translocation that comprises
      amplified chromosomal segments jumping to various telomeres. In this study, we
      identified a novel gene human JTB (Jumping Translocation Breakpoint) at 1q21,
      which fused with the telomeric repeats of acceptor telomeres in a case of JT.
      hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among 
      divergent eukaryotic species. JT results in a hJTB truncation, which potentially 
      produces an hJTB product devoid of the trans-membrane domain. hJTB is located in 
      a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). This 
      is the first report identifying the gene involved in unbalanced translocations at
      1q21.
FAU - Hatakeyama, S
AU  - Hatakeyama S
AD  - Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan.
FAU - Osawa, M
AU  - Osawa M
FAU - Omine, M
AU  - Omine M
FAU - Ishikawa, F
AU  - Ishikawa F
LA  - eng
SI  - GENBANK/AB016488
SI  - GENBANK/AB016489
SI  - GENBANK/AB016490
SI  - GENBANK/AB016491
SI  - GENBANK/AB016492
SI  - GENBANK/AB016493
SI  - GENBANK/AB016494
SI  - GENBANK/AB016495
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (JTB protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Differentiation/genetics
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Conserved Sequence
MH  - Epidermal Cells
MH  - Eukaryotic Cells
MH  - Female
MH  - Humans
MH  - Leukemia/genetics
MH  - Membrane Proteins/*genetics
MH  - Molecular Sequence Data
MH  - Myelodysplastic Syndromes/genetics
MH  - *Neoplasm Proteins
MH  - Neoplasms/*genetics
MH  - Ovarian Neoplasms/genetics
MH  - Sequence Homology, Amino Acid
MH  - *Translocation, Genetic
EDAT- 1999/05/13 00:00
MHDA- 1999/05/13 00:01
CRDT- 1999/05/13 00:00
PHST- 1999/05/13 00:00 [pubmed]
PHST- 1999/05/13 00:01 [medline]
PHST- 1999/05/13 00:00 [entrez]
AID - 10.1038/sj.onc.1202510 [doi]
PST - ppublish
SO  - Oncogene. 1999 Mar 25;18(12):2085-90. doi: 10.1038/sj.onc.1202510.