PMID- 10319863
OWN - NLM
STAT- MEDLINE
DCOM- 19990525
LR  - 20171116
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 22
IP  - 1
DP  - 1999 May
TI  - Inactivating mutations and overexpression of BCL10, a caspase recruitment
      domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).
PG  - 63-8
AB  - Mucosa-associated lymphoid tissue (MALT) lymphomas most frequently involve the
      gastrointestinal tract and are the most common subset of extranodal non-Hodgkin
      lymphoma (NHL). Here we describe overexpression of BCL10, a novel apoptotic
      signalling gene that encodes an amino-terminal caspase recruitment domain (CARD),
      in MALT lymphomas due to the recurrent t(1;14)(p22;q32). BCL10 cDNAs from
      t(1;14)-positive MALT tumours contained a variety of mutations, most resulting in
      truncations either in or carboxy terminal to the CARD. Wild-type BCL10 activated 
      NF-kappaB but induced apoptosis of MCF7 and 293 cells. CARD-truncation mutants
      were unable to induce cell death or activate NF-kappaB, whereas mutants with
      C-terminal truncations retained NF-kappaB activation but did not induce
      apoptosis. Mutant BCL10 overexpression might have a twofold lymphomagenic effect:
      loss of BCL10 pro-apoptosis may confer a survival advantage to MALT B-cells, and 
      constitutive NF-kappaB activation may provide both anti-apoptotic and
      proliferative signals mediated via its transcriptional targets.
FAU - Zhang, Q
AU  - Zhang Q
AD  - Department of Pathology and Laboratory Medicine, St. Jude Children's Research
      Hospital, Memphis, Tennessee 38105, USA.
FAU - Siebert, R
AU  - Siebert R
FAU - Yan, M
AU  - Yan M
FAU - Hinzmann, B
AU  - Hinzmann B
FAU - Cui, X
AU  - Cui X
FAU - Xue, L
AU  - Xue L
FAU - Rakestraw, K M
AU  - Rakestraw KM
FAU - Naeve, C W
AU  - Naeve CW
FAU - Beckmann, G
AU  - Beckmann G
FAU - Weisenburger, D D
AU  - Weisenburger DD
FAU - Sanger, W G
AU  - Sanger WG
FAU - Nowotny, H
AU  - Nowotny H
FAU - Vesely, M
AU  - Vesely M
FAU - Callet-Bauchu, E
AU  - Callet-Bauchu E
FAU - Salles, G
AU  - Salles G
FAU - Dixit, V M
AU  - Dixit VM
FAU - Rosenthal, A
AU  - Rosenthal A
FAU - Schlegelberger, B
AU  - Schlegelberger B
FAU - Morris, S W
AU  - Morris SW
LA  - eng
SI  - GENBANK/AF082283
SI  - GENBANK/AF097732
GR  - CA-27165/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - Binding Sites
MH  - Blotting, Northern
MH  - Caspases/*metabolism
MH  - Cell Death/genetics
MH  - Cell Line
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - DNA/chemistry/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation
MH  - NF-kappa B/metabolism
MH  - Neoplasm Proteins/chemistry/*genetics/metabolism
MH  - Protein Structure, Tertiary
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Translocation, Genetic
MH  - Tumor Cells, Cultured
EDAT- 1999/05/13 02:03
MHDA- 2001/03/23 10:01
CRDT- 1999/05/13 02:03
PHST- 1999/05/13 02:03 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/05/13 02:03 [entrez]
AID - 10.1038/8767 [doi]
PST - ppublish
SO  - Nat Genet. 1999 May;22(1):63-8. doi: 10.1038/8767.