PMID- 102659
OWN - NLM
STAT- MEDLINE
DCOM- 19790221
LR  - 20061115
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 182
IP  - 3
DP  - 1978 Dec 1
TI  - Genetic control of retinal ganglion cell projections.
PG  - 399-421
AB  - We have assessed the effects of 15 pigmentation mutations on the development of
      retinal ganglion cell projections in mice in two ways: (1) by analyzing the
      pattern of innervation of the ipsilateral lateral geniculate nucleus as mapped in
      autoradiograms of brains of animals killed 12 days after intravitreal injection
      of 3H-proline into one eye and (2) by determining the ratio of axonally
      transported radioactive protein in the contralateral and ipsilateral optic tracts
      after similar intravitreal injections. Analysis of the ratio of transported
      protein in the two optic tracts provides a new and useful assay of the degree of 
      decussation in experimental animals. The effects of the mutations on eye
      pigmentation, whole eye melanin content and relative tyrosinase activity also
      were examined. The degree of ipsilateral innervation generally correlates with
      the degree of pigmentation of the retinal pigment epithelium and with tyrosinase 
      activity. However, discrepancies have been found in ch and ce mutants. In these
      animals the pigment epithelium is well pigmented, and the area of ipsilateral
      innervation in the lateral geniculate nucleus is extensive, despite a high ratio 
      of label in contralateral to ipsilateral optic tracts and low tyrosinase
      activity. Furthermore, mice heterozygous for the c2J allele have pigmentation and
      optic projections that are normal even though tyrosinase is reduced to 40% of
      normal. The few anomalous results suggest that alternative or additional factors 
      may control optic axon projections.
FAU - LaVail, J H
AU  - LaVail JH
FAU - Nixon, R A
AU  - Nixon RA
FAU - Sidman, R L
AU  - Sidman RL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Melanins)
RN  - 0 (Retinal Pigments)
RN  - EC 1.14.18.1 (Monophenol Monooxygenase)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Geniculate Bodies/anatomy & histology
MH  - *Genotype
MH  - Hair Color
MH  - Melanins/analysis
MH  - Mice
MH  - Monophenol Monooxygenase/analysis
MH  - Mutation
MH  - Neurons/physiology
MH  - Retina/*analysis/anatomy & histology/cytology
MH  - Retinal Pigments
MH  - Visual Pathways/*anatomy & histology
EDAT- 1978/12/01 00:00
MHDA- 1978/12/01 00:01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 1978/12/01 00:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
AID - 10.1002/cne.901820304 [doi]
PST - ppublish
SO  - J Comp Neurol. 1978 Dec 1;182(3):399-421. doi: 10.1002/cne.901820304.