PMID- 102414 OWN - NLM STAT- MEDLINE DCOM- 19790221 LR - 20190613 IS - 0006-8993 (Print) IS - 0006-8993 (Linking) VI - 160 IP - 1 DP - 1979 Jan 5 TI - Demonstration of a specific localization of carbonic anhydrase C in the glial cells of rat CNS by an immunohistochemical method. PG - 47-55 AB - The localization of carbonic anhydrase C isoenzyme in the central nervous system (CNS) of the rat has been investigated using the indirect immunoperoxidase technique, at both optic and electron microscopic levels. Evidence is presented for a specific localization of the enzyme in the cytoplasm of the oligodendrocytes and astrocytes. Myelinated fibers show a weak staining. The positive reaction is restricted to the cytoplasmic areas of the myelin sheath and does not appear in the compact myelin. Neuronal cell bodies do not stain at all. A strong positive reaction to the antiserum was also observed in the choroid plexus. FAU - Roussel, G AU - Roussel G FAU - Delaunoy, J P AU - Delaunoy JP FAU - Nussbaum, J L AU - Nussbaum JL FAU - Mandel, P AU - Mandel P LA - eng PT - Journal Article PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 RN - EC 4.2.1.1 (Carbonic Anhydrases) SB - IM MH - Animals MH - Astrocytes/enzymology MH - Carbonic Anhydrases/*metabolism MH - Cerebellum/enzymology MH - Cerebral Cortex/enzymology MH - Choroid Plexus/enzymology MH - Corpus Callosum/enzymology MH - Cytoplasm/enzymology MH - Immunoenzyme Techniques MH - Myelin Sheath/enzymology MH - Neuroglia/*enzymology MH - Oligodendroglia/enzymology MH - Rats EDAT- 1979/01/05 00:00 MHDA- 1979/01/05 00:01 CRDT- 1979/01/05 00:00 PHST- 1979/01/05 00:00 [pubmed] PHST- 1979/01/05 00:01 [medline] PHST- 1979/01/05 00:00 [entrez] AID - 0006-8993(79)90599-7 [pii] AID - 10.1016/0006-8993(79)90599-7 [doi] PST - ppublish SO - Brain Res. 1979 Jan 5;160(1):47-55. doi: 10.1016/0006-8993(79)90599-7.