PMID- 10235444
OWN - NLM
STAT- MEDLINE
DCOM- 19990804
LR  - 20071114
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 81
IP  - 4
DP  - 1999 Apr
TI  - Nucleotide structure and characterization of the murine gene encoding the
      endothelial cell protein C receptor.
PG  - 585-8
AB  - The nucleotide sequence of the entire gene encoding the murine endothelial cell
      receptor for activated protein C (EPCR) has been determined. A total of 5303 bp
      of DNA was sequenced that included 4 exons and three introns, which constituted
      the coding region of the gene, as well as 393 bp upstream of the first exon and
      841 bp downstream of the last exon. From the locations of the introns in this
      gene and analysis of the exon structures, it is clear the EPCR gene is a member
      of the CD1 class of multiple histocompatibility proteins. and its cDNA sequence
      is nearly identical to that of CCD41, a centrosome-associated protein. All
      elements needed for RNA polymerase II-based transcription are predicted to exist 
      in the 5' uncoded region of the gene, and potential 3' regulatory sequences for
      efficient polyadenylation have been located at their optimal locations. A variety
      of highly probable transcription factor binding sites have been located in the 5'
      region of the gene. These data suggest that the EPCR gene is under efficient
      transcriptional control, and support the finding that this gene product may be
      involved in the inflammatory pathway.
FAU - Liang, Z
AU  - Liang Z
AD  - Department of Chemistry and Biochemistry and the W.M. Keck Center for Transgene
      Research, University of Notre Dame, Indiana 46556, USA.
FAU - Rosen, E D
AU  - Rosen ED
FAU - Castellino, F J
AU  - Castellino FJ
LA  - eng
SI  - GENBANK/AF162695
GR  - HL-19982/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (activated protein C receptor)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Blood Coagulation Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/metabolism
MH  - Receptors, Cell Surface/*genetics
MH  - TATA Box
MH  - Tumor Cells, Cultured
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
AID - 99040585 [pii]
PST - ppublish
SO  - Thromb Haemost. 1999 Apr;81(4):585-8.