PMID- 10234000
OWN - NLM
STAT- MEDLINE
DCOM- 19990601
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 10
DP  - 1999 May 15
TI  - Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the
      brain.
PG  - 3681-90
AB  - We have identified a mammalian opsin, encephalopsin, that shows strong and
      specific expression in the brain. Encephalopsin defines a new family of opsins
      and shows highest homology to vertebrate retinal and pineal opsins. Encephalopsin
      is highly expressed in the preoptic area and paraventricular nucleus of the
      hypothalamus, both regions implicated in encephalic photoreception in
      nonmammalian vertebrates. In addition, encephalopsin shows highly patterned
      expression in other regions of the brain, being enriched in selected regions of
      the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons,
      selected thalamic nuclei, and a subset of interneurons in the ventral horn of the
      spinal cord. Rostrocaudal gradients of encephalopsin expression are present in
      the cortex, cerebellum, and striatum. Radial stripes of encephalopsin expression 
      are seen in the cerebellum. In the cortex and cerebellum, encephalopsin
      expression is considerably higher and more highly patterned in the adult than in 
      the neonate. Encephalopsin is the first putative extraocular opsin identified in 
      mammals and may play a role in encephalic photoreception.
FAU - Blackshaw, S
AU  - Blackshaw S
AD  - The Johns Hopkins University, School of Medicine, Departments of Neuroscience,
      Pharmacology and Molecular Sciences, and Psychiatry, Baltimore, Maryland 21205,
      USA.
FAU - Snyder, S H
AU  - Snyder SH
LA  - eng
SI  - GENBANK/AF140241
SI  - GENBANK/AF140242
GR  - K05 DA000074/DA/NIDA NIH HHS/United States
GR  - DA-00268/DA/NIDA NIH HHS/United States
GR  - DA-00074/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Rod Opsins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/embryology/growth & development/*metabolism
MH  - Cerebellum/chemistry/embryology/growth & development
MH  - Cloning, Molecular
MH  - Diencephalon/chemistry/embryology/growth & development
MH  - Embryonic and Fetal Development/physiology
MH  - Humans
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*analysis
MH  - Rod Opsins/*analysis
MH  - Sequence Homology, Amino Acid
MH  - Spermatids/chemistry
MH  - Testis/chemistry/embryology/growth & development
PMC - PMC6782724
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 1999 May 15;19(10):3681-90.