PMID- 10233995
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 73
IP  - 6
DP  - 1999 Jun
TI  - Influenza A virus RNA polymerase has the ability to stutter at the
      polyadenylation site of a viral RNA template during RNA replication.
PG  - 5240-3
AB  - The viral polymerase of influenza virus, a negative-strand RNA virus, is believed
      to polyadenylate the mRNAs by stuttering at a stretch of five to seven uridine
      residues which are located close to the 5' ends of the viral RNA templates.
      However, a mechanism of polyadenylation based on a template-independent synthesis
      of the poly(A) tail has not been excluded. In this report, we present new
      evidence showing the inherent ability of the viral polymerase to stutter at the
      poly(U) stretch of a viral RNA template during RNA replication. Variants which
      possess 1- to 13-nucleotide-long insertions at the poly(U) stretch have been
      identified. These results support a stuttering mechanism for the polyadenylation 
      of influenza virus mRNAs.
FAU - Zheng, H
AU  - Zheng H
AD  - Department of Microbiology, Mount Sinai School of Medicine, New York, New York
      10029, USA.
FAU - Lee, H A
AU  - Lee HA
FAU - Palese, P
AU  - Palese P
FAU - Garcia-Sastre, A
AU  - Garcia-Sastre A
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Viral)
RN  - EC 2.7.7.6 (DNA-Directed RNA Polymerases)
RN  - EC 3.2.1.18 (Neuraminidase)
SB  - IM
MH  - Base Sequence
MH  - DNA-Directed RNA Polymerases/*physiology
MH  - Influenza A virus/*genetics/physiology
MH  - Molecular Sequence Data
MH  - Neuraminidase/genetics
MH  - RNA, Messenger/*metabolism
MH  - RNA, Viral/*biosynthesis
MH  - Transfection
MH  - Virus Replication
PMC - PMC112577
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
PST - ppublish
SO  - J Virol. 1999 Jun;73(6):5240-3.