PMID- 10233954
OWN - NLM
STAT- MEDLINE
DCOM- 19990607
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 73
IP  - 6
DP  - 1999 Jun
TI  - Identification of the murine Mx2 gene: interferon-induced expression of the Mx2
      protein from the feral mouse gene confers resistance to vesicular stomatitis
      virus.
PG  - 4925-30
AB  - The mouse genome contains two related interferon-regulated genes, Mx1 and Mx2.
      Whereas Mx1 codes for the nuclear 72-kDa protein that interferes with influenza
      virus replication after interferon treatment, the Mx2 gene is nonfunctional in
      all laboratory mouse strains examined, since its open reading frame (ORF) is
      interrupted by an insertional mutation and a subsequent frameshift mutation. In
      the present study, we demonstrate that Mx2 mRNA of cells from feral mouse strains
      NJL (Mus musculus musculus) and SPR (Mus spretus) differs from that of the
      laboratory mouse strains tested. The Mx2 mRNA of the feral strains contains a
      single long ORF consisting of 656 amino acids. We further show that Mx2 protein
      in the feral strains is expressed upon interferon treatment and localizes to the 
      cytoplasm much like the rat Mx2 protein, which inhibits vesicular stomatitis
      virus replication. Furthermore, transfected 3T3 cell lines of laboratory mouse
      origin expressing Mx2 from feral strains acquire slight resistance to vesicular
      stomatitis virus.
FAU - Jin, H K
AU  - Jin HK
AD  - Laboratory of Experimental Animal Science, Graduate School of Veterinary
      Medicine, Hokkaido University, Sapporo 060-0818, Japan.
FAU - Takada, A
AU  - Takada A
FAU - Kon, Y
AU  - Kon Y
FAU - Haller, O
AU  - Haller O
FAU - Watanabe, T
AU  - Watanabe T
LA  - eng
SI  - GENBANK/AB029920
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antiviral Agents)
RN  - 0 (DNA, Complementary)
RN  - 0 (Mx1 protein, mouse)
RN  - 0 (Mx1 protein, rat)
RN  - 0 (Mx2 protein, mouse)
RN  - 0 (Mx2 protein, rat)
RN  - 0 (Myxovirus Resistance Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 9008-11-1 (Interferons)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antiviral Agents/*physiology
MH  - Base Sequence
MH  - Cells, Cultured
MH  - DNA, Complementary/isolation & purification
MH  - *GTP-Binding Proteins
MH  - Interferons/*pharmacology
MH  - Mice/*genetics
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Myxovirus Resistance Proteins
MH  - Promoter Regions, Genetic
MH  - Proteins/*genetics/*physiology
MH  - RNA, Messenger/analysis
MH  - Rhabdoviridae Infections/*prevention & control
MH  - Transfection
MH  - Vesicular stomatitis Indiana virus/*physiology
MH  - Virus Replication
PMC - PMC112536
EDAT- 1999/05/11 00:00
MHDA- 1999/05/11 00:01
CRDT- 1999/05/11 00:00
PHST- 1999/05/11 00:00 [pubmed]
PHST- 1999/05/11 00:01 [medline]
PHST- 1999/05/11 00:00 [entrez]
AID - 10.1128/JVI.73.6.4925-4930.1999 [doi]
PST - ppublish
SO  - J Virol. 1999 Jun;73(6):4925-30. doi: 10.1128/JVI.73.6.4925-4930.1999.