PMID- 10232700
OWN - NLM
STAT- MEDLINE
DCOM- 19990622
LR  - 20121115
IS  - 1046-6673 (Print)
IS  - 1046-6673 (Linking)
VI  - 10
IP  - 5
DP  - 1999 May
TI  - Lessons on renal physiology from transgenic mice lacking aquaporin water
      channels.
PG  - 1126-35
AB  - Several aquaporin-type water channels are expressed in kidney: AQP1 in the
      proximal tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and
      AQP4 in the collecting duct; AQP6 in the papilla; and AQP7 in the proximal
      tubule. AQP2 is the vasopressin-regulated water channel that is important in
      hereditary and acquired diseases affecting urine-concentrating ability. It has
      been difficult to establish the roles of the other aquaporins in renal physiology
      because suitable aquaporin inhibitors are not available. One approach to the
      problem has been to generate and analyze transgenic knockout mice in which
      individual aquaporins have been selectively deleted by targeted gene disruption. 
      Phenotype analysis of kidney and extrarenal function in knockout mice has been
      very informative in defining the role of aquaporins in organ physiology and
      addressing basic questions regarding the route of transepithelial water transport
      and the mechanism of near iso-osmolar fluid reabsorption. This article describes 
      new renal physiologic insights revealed by phenotype analysis of
      aquaporin-knockout mice and the prospects for further basic and clinical
      developments.
FAU - Verkman, A S
AU  - Verkman AS
AD  - Department of Medicine, Cardiovascular Research Institute, University of
      California, San Francisco 94143-0521, USA. verkman@itsa.ucsf.edu
LA  - eng
GR  - DK35124/DK/NIDDK NIH HHS/United States
GR  - HL51854/HL/NHLBI NIH HHS/United States
GR  - HL59198/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Am Soc Nephrol
JT  - Journal of the American Society of Nephrology : JASN
JID - 9013836
RN  - 0 (Aquaporins)
SB  - IM
MH  - Animals
MH  - Aquaporins/*genetics
MH  - Genetic Therapy
MH  - Kidney/*physiology
MH  - Kidney Concentrating Ability/physiology
MH  - Kidney Tubules/physiology
MH  - Mice
MH  - Mice, Knockout/*genetics/physiology
MH  - Peritoneal Dialysis
MH  - Phenotype
RF  - 48
EDAT- 1999/05/08 00:00
MHDA- 1999/05/08 00:01
CRDT- 1999/05/08 00:00
PHST- 1999/05/08 00:00 [pubmed]
PHST- 1999/05/08 00:01 [medline]
PHST- 1999/05/08 00:00 [entrez]
PST - ppublish
SO  - J Am Soc Nephrol. 1999 May;10(5):1126-35.