PMID- 10231569
OWN - NLM
STAT- MEDLINE
DCOM- 19990628
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 231
IP  - 1-2
DP  - 1999 Apr 29
TI  - TLR6: A novel member of an expanding toll-like receptor family.
PG  - 59-65
AB  - Drosophila Toll protein is shown to activate the innate immune system in adult
      and regulate the dorsoventral patterning in the developing embryo. Recently, five
      human homologs of Drosophila Toll, designated as Toll-like receptors (TLRs), have
      been identified and shown to play a role in the innate immune response. We report
      here the molecular cloning and characterization of a new member of Toll-like
      receptor family, Toll-like receptor 6 (TLR6). Human and murine TLR6 are type-I
      transmembrane receptors that contain both an extracellular leucine-rich repeat
      (LRR) domain and a cytoplasmic Toll/IL-1 receptor (IL-1R)-like region. The amino 
      acid sequence of human TLR6 (hTLR6) is most similar to that of hTLR1 with 69%
      identity. RT-PCR analysis revealed that murine TLR6 is expressed predominantly in
      spleen, thymus, ovary and lung. Like other TLR family members, constitutively
      active TLR6 activates both NF-kappaB and c-Jun N-terminal kinase (JNK). The TLR6 
      gene, as well as the TLR1 gene, mapped to the proximal region of murine
      chromosome 5 within 1.7cM of each other. These results suggest that TLR6 is a
      novel member of an expanding TLR family.
FAU - Takeuchi, O
AU  - Takeuchi O
AD  - Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho,
      Nishinomiya, Hyogo 663-8501, Japan.
FAU - Kawai, T
AU  - Kawai T
FAU - Sanjo, H
AU  - Sanjo H
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Takeda, K
AU  - Takeda K
FAU - Akira, S
AU  - Akira S
LA  - eng
SI  - GENBANK/AB020807
SI  - GENBANK/AB020808
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR6 protein, human)
RN  - 0 (Tlr6 protein, mouse)
RN  - 0 (Toll-Like Receptor 1)
RN  - 0 (Toll-Like Receptor 6)
RN  - 0 (Toll-Like Receptors)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - DNA, Complementary
MH  - Drosophila/genetics
MH  - *Drosophila Proteins
MH  - Enzyme Activation
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases
MH  - Membrane Glycoproteins/*genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Mitogen-Activated Protein Kinases
MH  - Molecular Sequence Data
MH  - NF-kappa B/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Cell Surface/*genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Toll-Like Receptor 1
MH  - Toll-Like Receptor 6
MH  - Toll-Like Receptors
EDAT- 1999/05/08 00:00
MHDA- 1999/05/08 00:01
CRDT- 1999/05/08 00:00
PHST- 1999/05/08 00:00 [pubmed]
PHST- 1999/05/08 00:01 [medline]
PHST- 1999/05/08 00:00 [entrez]
AID - S0378-1119(99)00098-0 [pii]
AID - 10.1016/s0378-1119(99)00098-0 [doi]
PST - ppublish
SO  - Gene. 1999 Apr 29;231(1-2):59-65. doi: 10.1016/s0378-1119(99)00098-0.