PMID- 10231560
OWN - NLM
STAT- MEDLINE
DCOM- 19990610
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1450
IP  - 1
DP  - 1999 May 6
TI  - PKCnu, a new member of the protein kinase C family, composes a fourth subfamily
      with PKCmu.
PG  - 99-106
AB  - Members of the protein kinase C (PKC) family of serine/threonine kinases are
      thought to play critical roles in the regulation of cellular differentiation and 
      proliferation in many cell types. An additional member of the PKC family was
      identified through human expressed sequence tag (EST) database search and its
      full length cDNA was isolated. Sequence analysis revealed that the predicted
      translation product was composed of 890 amino acid residues and that the protein 
      has 77.3% similarity to human PKC mu (PKCmu) and 77. 4% similarity to mouse PKD
      (the mouse homolog of PKCmu). We designated the new member as protein kinase C nu
      (PKCnu). The PKCnu messenger RNA was ubiquitously expressed in various tissues
      when analyzed by Northern blots and reverse transcriptase-coupled polymerase
      chain reaction (PCR) analyses. The chromosomal location of the gene was
      determined between markers WI-9798 and D2S177 on chromosome 2p21 region by
      PCR-based methods with both a human/rodent monochromosomal hybrid cell panel and 
      a radiation hybrid mapping panel.
FAU - Hayashi, A
AU  - Hayashi A
AD  - Genome Research Group, National Institute of Radiological Sciences, Anagawa
      4-9-1, Inage-ku, Chiba 263-8555, Japan.
FAU - Seki, N
AU  - Seki N
FAU - Hattori, A
AU  - Hattori A
FAU - Kozuma, S
AU  - Kozuma S
FAU - Saito, T
AU  - Saito T
LA  - eng
SI  - GENBANK/AB015982
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (DNA, Complementary)
RN  - 0 (Isoenzymes)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.- (protein kinase C nu)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - DNA, Complementary/chemistry
MH  - Databases as Topic
MH  - Humans
MH  - Isoenzymes/*genetics
MH  - Molecular Sequence Data
MH  - Protein Kinase C/biosynthesis/chemistry/*genetics
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
EDAT- 1999/05/08 00:00
MHDA- 1999/05/08 00:01
CRDT- 1999/05/08 00:00
PHST- 1999/05/08 00:00 [pubmed]
PHST- 1999/05/08 00:01 [medline]
PHST- 1999/05/08 00:00 [entrez]
AID - S0167-4889(99)00040-3 [pii]
AID - 10.1016/s0167-4889(99)00040-3 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 May 6;1450(1):99-106. doi:
      10.1016/s0167-4889(99)00040-3.