PMID- 10230405
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 3
IP  - 4
DP  - 1999 Apr
TI  - Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment:
      integration of hormone signaling in reproduction and stress.
PG  - 521-6
AB  - Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor that serves as an
      essential regulator of many hormone-induced genes in the vertebrate endocrine
      system. The apparent absence of a SF-1 ligand prompted speculation that this
      receptor is regulated by alternative mechanisms involving signal transduction
      pathways. Here we show that maximal SF-1-mediated transcription and interaction
      with general nuclear receptor cofactors depends on phosphorylation of a single
      serine residue (Ser-203) located in a major activation domain (AF-1) of the
      protein. Moreover, phosphorylation-dependent SF-1 activation is likely mediated
      by the mitogen-activated protein kinase (MAPK) signaling pathway. We propose that
      this single modification of SF-1 and the subsequent recruitment of nuclear
      receptor cofactors couple extracellular signals to steroid and peptide hormone
      synthesis, thereby maintaining dynamic homeostatic responses in stress and
      reproduction.
FAU - Hammer, G D
AU  - Hammer GD
AD  - Department of Physiology, University of California, San Francisco 94143-0444,
      USA.
FAU - Krylova, I
AU  - Krylova I
FAU - Zhang, Y
AU  - Zhang Y
FAU - Darimont, B D
AU  - Darimont BD
FAU - Simpson, K
AU  - Simpson K
FAU - Weigel, N L
AU  - Weigel NL
FAU - Ingraham, H A
AU  - Ingraham HA
LA  - eng
GR  - K08/PHS HHS/United States
GR  - R01-CA57539/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Fushi Tarazu Transcription Factors)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NCOR2 protein, human)
RN  - 0 (NR5A1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Co-Repressor 2)
RN  - 0 (Nuclear Receptor Coactivator 2)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Repressor Proteins)
RN  - 0 (Steroidogenic Factor 1)
RN  - 0 (Transcription Factors)
RN  - 452VLY9402 (Serine)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Epidermal Growth Factor/pharmacology
MH  - Fushi Tarazu Transcription Factors
MH  - Genes, Reporter
MH  - Homeodomain Proteins
MH  - Humans
MH  - Mutation
MH  - Nuclear Proteins/genetics
MH  - Nuclear Receptor Co-Repressor 2
MH  - Nuclear Receptor Coactivator 2
MH  - Phosphorylation
MH  - Protein Processing, Post-Translational
MH  - Receptors, Cytoplasmic and Nuclear/*metabolism
MH  - Repressor Proteins/metabolism
MH  - Reproduction
MH  - Serine/metabolism
MH  - Signal Transduction/*physiology
MH  - Steroidogenic Factor 1
MH  - Stress, Physiological
MH  - Transcription Factors/genetics/*metabolism
MH  - Transcriptional Activation
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/05/07 00:00
MHDA- 1999/05/07 00:01
CRDT- 1999/05/07 00:00
PHST- 1999/05/07 00:00 [pubmed]
PHST- 1999/05/07 00:01 [medline]
PHST- 1999/05/07 00:00 [entrez]
AID - S1097-2765(00)80480-3 [pii]
AID - 10.1016/s1097-2765(00)80480-3 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Apr;3(4):521-6. doi: 10.1016/s1097-2765(00)80480-3.