PMID- 10230395
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 3
IP  - 4
DP  - 1999 Apr
TI  - A role for a PDZ protein in the early secretory pathway for the targeting of
      proTGF-alpha to the cell surface.
PG  - 423-33
AB  - In general, plasma membrane integral proteins, such as the membrane-anchored
      growth factor proTGF-alpha, are assumed to be transported to the cell surface via
      a nonregulated, constitutive pathway. proTGF-alpha C-terminal mutants are
      retained in an early secretory compartment. Here, using a two-hybrid screen, we
      identify two TACIPs (proTGF-alpha cytoplasmic domain-interacting proteins) that
      contain PDZ domains and do not interact with proTGF-alpha C-terminal mutants. The
      binding specificity of one of them, TACIP18 (previously identified and named
      Syntenin or mda-9), coincides with that of the component that possibly mediates
      the normal trafficking of proTGF-alpha. TACIP18 colocalizes and interacts
      specifically with immature, intracellular forms of proTGF-alpha. Therefore, it
      appears that the interaction of TACIP18 with proTGF-alpha in the early secretory 
      pathway is necessary for the targeting of the latter to the cell surface.
FAU - Fernandez-Larrea, J
AU  - Fernandez-Larrea J
AD  - Laboratori de Recerca Oncologica, Hospital General Universitari Vall d'Hebron,
      Barcelona, Spain.
FAU - Merlos-Suarez, A
AU  - Merlos-Suarez A
FAU - Urena, J M
AU  - Urena JM
FAU - Baselga, J
AU  - Baselga J
FAU - Arribas, J
AU  - Arribas J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Protein Precursors)
RN  - 0 (Protein Sorting Signals)
RN  - 0 (Proteoglycans)
RN  - 0 (SDC2 protein, human)
RN  - 0 (SDCBP protein, human)
RN  - 0 (Syntenins)
RN  - 0 (Transforming Growth Factor alpha)
RN  - 0 (protransforming growth factor alpha)
RN  - 0 (syntrophin alpha1)
RN  - 149769-25-5 (Syndecan-2)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - CHO Cells
MH  - Calcium-Binding Proteins
MH  - Carrier Proteins/metabolism
MH  - Cricetinae
MH  - HeLa Cells
MH  - Humans
MH  - Immunohistochemistry
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Membrane Glycoproteins/metabolism
MH  - Membrane Proteins
MH  - Molecular Sequence Data
MH  - Muscle Proteins
MH  - Mutation
MH  - Protein Precursors/genetics/*metabolism
MH  - Protein Sorting Signals/chemistry
MH  - Proteoglycans/metabolism
MH  - Syndecan-2
MH  - Syntenins
MH  - Transfection
MH  - Transforming Growth Factor alpha/genetics/*metabolism
EDAT- 1999/05/07 00:00
MHDA- 1999/05/07 00:01
CRDT- 1999/05/07 00:00
PHST- 1999/05/07 00:00 [pubmed]
PHST- 1999/05/07 00:01 [medline]
PHST- 1999/05/07 00:00 [entrez]
AID - S1097-2765(00)80470-0 [pii]
AID - 10.1016/s1097-2765(00)80470-0 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Apr;3(4):423-33. doi: 10.1016/s1097-2765(00)80470-0.