PMID- 10229813
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20171116
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 10
DP  - 1999 May 15
TI  - Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on
      cytotoxic T cells.
PG  - 5800-4
AB  - Leukocyte associated Ig-like receptor-1 (LAIR-1) is a surface molecule expressed 
      on human mononuclear leukocytes that functions as an inhibitory receptor on human
      NK cells. In addition to NK cells, LAIR-1 is expressed on T cells, B cells,
      macrophages, and dendritic cells. Most cells express two biochemically distinct
      forms of LAIR-1, which we now show are likely alternative splice variants of the 
      same gene. Cross-linking of LAIR-1 on human T cell clones results in inhibition
      of cytotoxicity only in T cell clones that lack CD28 and are able to
      spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of 
      freshly isolated T cells, which is thought to be mainly due to "effector" T
      cells, can be inhibited by anti-LAIR-1 mAb. Thus, LAIR-1 functions as an
      inhibitory receptor not only on NK cells, but also on human T cells. This
      indicates that LAIR-1 provides a mechanism of regulation of effector T cells and 
      may play a role in the inhibition of unwanted bystander responses mediated by
      Ag-specific T cells.
FAU - Meyaard, L
AU  - Meyaard L
AD  - Department of Immunobiology, DNAX Research Institute of Molecular and Cellular
      Biology, Palo Alto, CA 94304, USA. l.meyaard@lab.azu.nl
FAU - Hurenkamp, J
AU  - Hurenkamp J
FAU - Clevers, H
AU  - Clevers H
FAU - Lanier, L L
AU  - Lanier LL
FAU - Phillips, J H
AU  - Phillips JH
LA  - eng
SI  - GENBANK/AF109683
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CD28 Antigens)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (leukocyte-associated immunoglobulin-like receptor 1)
SB  - AIM
SB  - IM
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - CD28 Antigens/immunology
MH  - Clone Cells
MH  - Cytotoxicity, Immunologic
MH  - Humans
MH  - Jurkat Cells
MH  - Killer Cells, Natural/*immunology
MH  - Molecular Sequence Data
MH  - Receptors, Immunologic/genetics/*immunology
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 1999/05/07 00:00
MHDA- 1999/05/07 00:01
CRDT- 1999/05/07 00:00
PHST- 1999/05/07 00:00 [pubmed]
PHST- 1999/05/07 00:01 [medline]
PHST- 1999/05/07 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 May 15;162(10):5800-4.