PMID- 10229804
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20171116
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 10
DP  - 1999 May 15
TI  - CDw150 associates with src-homology 2-containing inositol phosphatase and
      modulates CD95-mediated apoptosis.
PG  - 5719-27
AB  - CDw150, a receptor up-regulated on activated T or B lymphocytes, has a key role
      in regulating B cell proliferation. Patients with X-linked lymphoproliferative
      disease have mutations in a gene encoding a protein, DSHP/SAP, which interacts
      with CDw150 and is expressed in B cells. Here we show that CDw150 on B cells
      associates with two tyrosine-phosphorylated proteins, 59 kDa and 145 kDa in size.
      The 59-kDa protein was identified as the Src-family kinase Fgr. The 145-kDa
      protein is the inositol polyphosphate 5'-phosphatase, SH2-containing inositol
      phosphatase (SHIP). Both Fgr and SHIP interact with phosphorylated tyrosines in
      CDw150's cytoplasmic tail. Ligation of CDw150 induces the rapid dephosphorylation
      of both SHIP and CDw150 as well as the association of Lyn and Fgr with SHIP.
      CD95/Fas-mediated apoptosis is enhanced by signaling via CDw150, and CDw150
      ligation can override CD40-induced rescue of CD95-mediated cell death. The
      ability of CDw150 to regulate cell death does not correlate with serine
      phosphorylation of the Akt kinase, but does correlate with SHIP tyrosine
      dephosphorylation. Thus, the CDw150 receptor may function to regulate the fate of
      activated B cells via SHIP as well as via the DSHP/SAP protein defective in
      X-linked lymphoproliferative disease patients.
FAU - Mikhalap, S V
AU  - Mikhalap SV
AD  - Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, Academy 
      of Science of Ukraine, Kiev, Ukraine.
FAU - Shlapatska, L M
AU  - Shlapatska LM
FAU - Berdova, A G
AU  - Berdova AG
FAU - Law, C L
AU  - Law CL
FAU - Clark, E A
AU  - Clark EA
FAU - Sidorenko, S P
AU  - Sidorenko SP
LA  - eng
GR  - GM37905/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (fas Receptor)
RN  - 169535-43-7 (Signaling Lymphocytic Activation Molecule Family Member 1)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (proto-oncogene proteins c-fgr)
RN  - EC 2.7.10.2 (src-Family Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - EC 3.1.3.86 (INPPL1 protein, human)
RN  - EC 3.1.3.86 (Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases)
SB  - AIM
SB  - IM
MH  - Antigens, CD
MH  - *Apoptosis
MH  - B-Lymphocytes/*metabolism
MH  - Carrier Proteins/metabolism
MH  - Glycoproteins/*metabolism
MH  - Immunoglobulins/*metabolism
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Leukocyte Common Antigens/metabolism
MH  - Lymphoproliferative Disorders/immunology
MH  - Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
MH  - Phosphoric Monoester Hydrolases/*metabolism
MH  - Protein Binding
MH  - *Protein-Serine-Threonine Kinases
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-akt
MH  - Receptor Aggregation
MH  - Receptors, Cell Surface
MH  - Signal Transduction
MH  - Signaling Lymphocytic Activation Molecule Family Member 1
MH  - fas Receptor/*metabolism
MH  - src Homology Domains
MH  - src-Family Kinases
EDAT- 1999/05/07 00:00
MHDA- 1999/05/07 00:01
CRDT- 1999/05/07 00:00
PHST- 1999/05/07 00:00 [pubmed]
PHST- 1999/05/07 00:01 [medline]
PHST- 1999/05/07 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 May 15;162(10):5719-27.