PMID- 10228029
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20181201
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 9
DP  - 1999 May 1
TI  - Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial
      cells.
PG  - 5490-7
AB  - We describe a novel mouse CXC chemokine that is selectively expressed in lung
      epithelial cells and up-regulated in various lung inflammation models. Although
      this chemokine clusters with other ELR-CXC chemokines, none of them can
      confidently be assigned to be its human homologue based on sequence identity. In 
      addition, the highly restricted mRNA tissue distribution of this chemokine
      differentiates it from all previously described chemokines: Lungkine could not be
      detected in any of the 70 cDNA libraries analyzed corresponding to specific
      murine cell populations and tissues. High levels of Lungkine mRNA were
      specifically detected in the lung and at lower levels in fetal lung tissue by
      Northern blot and in situ hybridization, suggesting a potential role for this
      chemokine during lung development. Moreover, Lungkine protein is secreted into
      the airway spaces and induces the in vitro and in vivo migration of neutrophils, 
      suggesting that it is involved in lung-specific neutrophil trafficking. Using
      fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome
      5.
FAU - Rossi, D L
AU  - Rossi DL
AD  - Department of Immunobiology, DNAX Research Institute of Molecular and Cellular
      Biology, Palo Alto, CA 94304, USA.
FAU - Hurst, S D
AU  - Hurst SD
FAU - Xu, Y
AU  - Xu Y
FAU - Wang, W
AU  - Wang W
FAU - Menon, S
AU  - Menon S
FAU - Coffman, R L
AU  - Coffman RL
FAU - Zlotnik, A
AU  - Zlotnik A
LA  - eng
SI  - GENBANK/AF082859
PT  - Journal Article
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cxcl15 protein, mouse)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
SB  - AIM
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bronchi/chemistry/cytology/immunology/*metabolism
MH  - Bronchoalveolar Lavage Fluid/chemistry/immunology
MH  - Cell Movement/immunology
MH  - Chemokines, CXC/*biosynthesis/chemistry/genetics/metabolism
MH  - Chemotaxis, Leukocyte/immunology
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry
MH  - Epithelial Cells/chemistry/immunology/*metabolism
MH  - Granulocytes/immunology
MH  - Humans
MH  - Inflammation/immunology/metabolism/pathology
MH  - Lung/chemistry/immunology/*metabolism/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Molecular Sequence Data
MH  - RNA, Messenger/biosynthesis
MH  - Up-Regulation/immunology
EDAT- 1999/05/05 00:00
MHDA- 1999/05/05 00:01
CRDT- 1999/05/05 00:00
PHST- 1999/05/05 00:00 [pubmed]
PHST- 1999/05/05 00:01 [medline]
PHST- 1999/05/05 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 May 1;162(9):5490-7.