PMID- 10227969
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20091119
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 162
IP  - 9
DP  - 1999 May 1
TI  - Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1
      receptor-related protein as an essential IL-18 binding receptor.
PG  - 5041-4
AB  - IL-18 is a proinflammatory cytokine that plays an important role in NK cell
      activation and Th1 cell response. Recently IL-1R-related protein (IL-1Rrp) has
      been cloned as the receptor for IL-18. However, the functional role of IL-1Rrp is
      still controversial due to its low affinity to IL-18 as well as the possibility
      of the presence of another high-affinity binding receptor. In the present study, 
      we have generated and characterized IL-1Rrp-deficient mice. The binding of murine
      rIL-18 was not detected in Th1-developing splenic CD4+ T cells isolated from
      IL-1Rrp-deficient mice. The activation of NF-kappa B or c-Jun N-terminal kinase
      were also not observed in the Th1 cells. NK cells from IL-1Rrp-deficient mice had
      defects in cytolytic activity and IFN-gamma production in response to IL-18. Th1 
      cell development was also impaired in IL-1Rrp-deficient mice. These data
      demonstrate that IL-1Rrp is a ligand-binding receptor that is essential for
      IL-18-mediated signaling events.
FAU - Hoshino, K
AU  - Hoshino K
AD  - Department of Appropriate Technology Development, Research Institute,
      International Medical Center of Japan, Tokyo, Japan.
FAU - Tsutsui, H
AU  - Tsutsui H
FAU - Kawai, T
AU  - Kawai T
FAU - Takeda, K
AU  - Takeda K
FAU - Nakanishi, K
AU  - Nakanishi K
FAU - Takeda, Y
AU  - Takeda Y
FAU - Akira, S
AU  - Akira S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Il18r1 protein, mouse)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-18 Receptor alpha Subunit)
RN  - 0 (NF-kappa B)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-18)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - AIM
SB  - IM
SB  - X
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Cell Differentiation/genetics/immunology
MH  - Cytotoxicity, Immunologic/genetics
MH  - DNA/immunology
MH  - Enzyme Activation/genetics/immunology
MH  - Gene Targeting
MH  - Interleukin-18/*metabolism/physiology
MH  - Interleukin-18 Receptor alpha Subunit
MH  - JNK Mitogen-Activated Protein Kinases
MH  - Killer Cells, Natural/immunology/pathology
MH  - Mice
MH  - Mice, Knockout/genetics/*immunology
MH  - *Mitogen-Activated Protein Kinases
MH  - NF-kappa B/metabolism
MH  - Protein Binding/genetics/immunology
MH  - Proteins/*genetics/metabolism
MH  - Receptors, Interleukin/*deficiency/*genetics
MH  - Receptors, Interleukin-18
MH  - Sequence Deletion
MH  - Spleen/immunology/pathology
MH  - Th1 Cells/pathology
EDAT- 1999/05/05 00:00
MHDA- 1999/05/05 00:01
CRDT- 1999/05/05 00:00
PHST- 1999/05/05 00:00 [pubmed]
PHST- 1999/05/05 00:01 [medline]
PHST- 1999/05/05 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1999 May 1;162(9):5041-4.