PMID- 10226592
OWN - NLM
STAT- MEDLINE
DCOM- 19990520
LR  - 20041117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 1A
DP  - 1999 Jan-Feb
TI  - Identification of URIM, a novel gene up-regulated in metastasis.
PG  - 525-30
AB  - URIM (Up-Regulated In Metastasis) was identified as a new gene by Differential
      Display Technique during investigation of the transcriptional pattern of a
      metastasizing (NMCL-1) and a non-metastasizing (530) human melanoma cell line.
      The protein is encoded by 206 amino acids with an isoelectric point of 10.4. In
      addition, URIM displays a putative nuclear localization signal and a putative
      leucine zipper suggesting that URIM may function as a nuclear protein. Expression
      of URIM in several normal tissues and tumor cell lines was studied by Northern
      blotting. Surprisingly, 17 fold increased steady-state mRNA levels for URIM were 
      detected in three cell lines derived from bone marrow micrometastasis of mammary 
      carcinoma and one mammary carcinoma cell line derived from ascites fluid compared
      to normal epithelial cells from mammary gland and two cell lines derived from
      primary mammary carcinoma. These findings indicate that expression of URIM might 
      be deregulated in metastases of different types of tumors.
FAU - Hildebrandt, T
AU  - Hildebrandt T
AD  - Boehringer Mannheim GmbH, Penzberg, Germany.
FAU - Preiherr, J
AU  - Preiherr J
FAU - Klostermann, S
AU  - Klostermann S
FAU - Kaul, S
AU  - Kaul S
FAU - Zendman, A J
AU  - Zendman AJ
FAU - Van Muijen, G N
AU  - Van Muijen GN
FAU - Weidle, U H
AU  - Weidle UH
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (DNA, Complementary)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - DNA, Complementary/chemistry
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Melanoma/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/*genetics
MH  - Neoplasm Transplantation
MH  - RNA, Messenger/analysis
MH  - Transplantation, Heterologous
MH  - Tumor Cells, Cultured
EDAT- 1999/05/05 00:00
MHDA- 1999/05/05 00:01
CRDT- 1999/05/05 00:00
PHST- 1999/05/05 00:00 [pubmed]
PHST- 1999/05/05 00:01 [medline]
PHST- 1999/05/05 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Jan-Feb;19(1A):525-30.