PMID- 10225288
OWN - NLM
STAT- MEDLINE
DCOM- 19990630
LR  - 20181130
IS  - 0928-8244 (Print)
IS  - 0928-8244 (Linking)
VI  - 23
IP  - 4
DP  - 1999 Apr
TI  - An investigation into the antimicrobial effects of adrenomedullin on members of
      the skin, oral, respiratory tract and gut microflora.
PG  - 289-93
AB  - Adrenomedullin, a novel vasoactive peptide, is known to be expressed by many
      surface epithelial cells and it was postulated that this peptide may have a
      protective role. The objective of the study was to assess the antimicrobial
      activity of adrenomedullin against members of the human skin, oral, respiratory
      tract and gut microflora using disc diffusion and broth microdilution assays. All
      strains of bacteria screened in an agar diffusion assay were sensitive;
      gram-positive and gram-negative bacteria were equally susceptible. No activity
      against the yeast Candida albicans was observed. In a broth microdilution assay, 
      minimum inhibitory and minimum bacteriocidal concentrations ranged from 7.75 x
      10(-1) to 12.5 microg ml(-1) and 0.003 to > 25.0 microg ml(-1), respectively. We 
      propose an antimicrobial role for adrenomedullin. participating in the prevention
      of local infection, thus contributing to host defence systems.
FAU - Allaker, R P
AU  - Allaker RP
AD  - Department of Oral Microbiology, St Bartholomew's and the Royal London School of 
      Medicine and Dentistry, UK. r.p.allaker@mds.qmw.ac.uk
FAU - Zihni, C
AU  - Zihni C
FAU - Kapas, S
AU  - Kapas S
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEMS Immunol Med Microbiol
JT  - FEMS immunology and medical microbiology
JID - 9315554
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Peptides)
RN  - 148498-78-6 (Adrenomedullin)
SB  - IM
MH  - Adrenomedullin
MH  - Anti-Bacterial Agents
MH  - Anti-Infective Agents/*pharmacology
MH  - Candida albicans/*drug effects
MH  - Gram-Negative Bacteria/*drug effects
MH  - Gram-Positive Bacteria/*drug effects
MH  - Humans
MH  - Intestines/microbiology
MH  - Peptides/*pharmacology
MH  - Respiratory System/microbiology
MH  - Skin/microbiology
EDAT- 1999/05/04 00:00
MHDA- 1999/05/04 00:01
CRDT- 1999/05/04 00:00
PHST- 1999/05/04 00:00 [pubmed]
PHST- 1999/05/04 00:01 [medline]
PHST- 1999/05/04 00:00 [entrez]
AID - S0928-8244(98)00148-5 [pii]
AID - 10.1111/j.1574-695X.1999.tb01250.x [doi]
PST - ppublish
SO  - FEMS Immunol Med Microbiol. 1999 Apr;23(4):289-93. doi:
      10.1111/j.1574-695X.1999.tb01250.x.